Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Kita 21 Nishi 11, Sapporo 001-0021, Japan.
J Am Chem Soc. 2012 Feb 29;134(8):3695-8. doi: 10.1021/ja3001584. Epub 2012 Feb 13.
The interaction of two IR chromophores yields a strong vibrational circular dichroism couplet whose sign reflects the absolute configuration of the molecule. We present a method to determine absolute configuration of a chiral molecule based on this couplet without need of theoretical calculation. Not only can this method analyze various molecules whose absolute configuration is difficult to determine by other spectroscopic methods, but also it can significantly enhance VCD signals.
两个 IR 发色团的相互作用产生了一个强的振动圆二色性偶极子，其符号反映了分子的绝对构型。我们提出了一种基于该偶极子而无需理论计算即可确定手性分子绝对构型的方法。该方法不仅可以分析其他光谱方法难以确定绝对构型的各种分子，而且可以显著增强 VCD 信号。
