Sweileh Waleed M, Ihbesheh Manal S, Jarar Ikhlas S, Sawalha Ansam F, Abu Taha Adham S, Zyoud Sa'ed H, Morisky Donald E
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine.
Curr Clin Pharmacol. 2012 Feb 1;7(1):49-55. doi: 10.2174/157488412799218761.
In Arab and Muslim-dominated countries, spirituality and religiosity shape the belief and practices toward chronic illnesses. No previous studies were published to assess adherence to and satisfaction with antipsychotic medications in persons with schizophrenia in the Arab world.
To assess medication adherence and treatment satisfaction with antipsychotics in a sample of Palestinian people with schizophrenia.
Medication adherence was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8). Treatment satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Psychiatric symptoms were assessed using the expanded Brief Psychiatric Rating Scale (BPRS-E). Data were entered and statistically analyzed using SPSS 16 for windows.
A convenience sample of 131 persons with schizophrenia was studied. Based on MMAS-8, 44 persons (33.6%) had a low rate, 58 (44.3%) had a medium rate and 29 (22.1%) had a high rate of adherence. Age was significantly correlated (P=0.028) with adherence score. However, variables like use of monotherapy or atypical or depot antipsychotics were not significantly associated with higher adherence. The means of satisfaction with regard to effectiveness, side effects, convenience and global satisfaction were 72.6 ± 20.5, 67.9 ± 31.47, 63.2 ± 14.3 and 63.1 ± 18.8 respectively. There was a significant difference in the means of effectiveness (P < 0.01), convenience (P < 0.01), global satisfaction (P < 0.01), but not side effects domains (P=0.1) among persons with different levels of adherence. Furthermore, there was a significant difference in the means of positive symptom score (P < 0.01), manic (P < 0.01) and depression (P < 0.01) but not negative symptom score (P=0.4) among persons with different levels of adherence.
Medication nonadherence was common and was associated with low treatment satisfaction scores and poor psychiatric scores. Medication related factors had insignificant effects on adherence scores.
在阿拉伯和穆斯林占主导的国家，精神性和宗教性塑造了对慢性病的信念和行为。此前尚无研究评估阿拉伯世界精神分裂症患者对抗精神病药物的依从性和满意度。
评估巴勒斯坦精神分裂症患者样本对抗精神病药物的药物依从性和治疗满意度。
使用8项Morisky药物依从性量表（MMAS - 8）评估药物依从性。使用药物治疗满意度问卷（TSQM 1.4）评估治疗满意度。使用扩展的简明精神病评定量表（BPRS - E）评估精神症状。数据录入并使用适用于Windows的SPSS 16进行统计分析。
对131名精神分裂症患者的便利样本进行了研究。根据MMAS - 8，44人（33.6%）依从率低，58人（44.3%）依从率中等，29人（22.1%）依从率高。年龄与依从性得分显著相关（P = 0.028）。然而，如使用单一疗法、非典型或长效抗精神病药物等变量与更高的依从性无显著关联。在有效性、副作用、便利性和总体满意度方面的满意度均值分别为72.6±20.5、67.9±31.47、63.2±14.3和63.1±18.8。不同依从性水平的患者在有效性（P < 0.01）、便利性（P < 0.01）、总体满意度（P < 0.01）方面的均值存在显著差异，但在副作用领域（P = 0.1）无显著差异。此外，不同依从性水平的患者在阳性症状得分（P < 0.01）、躁狂（P < 0.01）和抑郁（P < 0.01）方面的均值存在显著差异，但在阴性症状得分（P = 0.4）方面无显著差异。
药物不依从情况常见，且与低治疗满意度得分和差的精神症状评分相关。药物相关因素对依从性得分影响不显著。
