Rapier Research Ltd, Great Milton, Oxford, United Kingdom.
Drug Discov Today. 2012 Jun;17(11-12):538-43. doi: 10.1016/j.drudis.2012.01.010. Epub 2012 Jan 25.
Medicinal chemistry makes a vital contribution to small molecule drug discovery, and the quality of it contributes directly to research effectiveness as well as to downstream costs, speed and survival in development. In recent years, the discipline of medicinal chemistry has evolved and witnessed many noteworthy contributions that propose and offer potential improvements to medicinal chemistry practice; however, the impact of these ideas is limited by their acceptance and deployment into every-day activity and, as a result, the quality of medicinal chemistry remains variable. For the good of the industry and the medicinal chemistry discipline, there is a need to move from retrospective learning to prospective control of medicinal chemistry practice to improve cost effectiveness, probability of success and survival rates.
药物化学对小分子药物发现做出了重要贡献，其质量直接影响研究效果以及下游的开发成本、速度和成功率。近年来，药物化学领域不断发展，出现了许多值得关注的贡献，为药物化学实践提出了潜在的改进建议；然而，这些想法的影响受到其被接受和应用于日常活动的限制，因此药物化学的质量仍然存在差异。为了行业和药物化学学科的利益，有必要从回顾性学习转变为前瞻性控制药物化学实践，以提高成本效益、成功率和生存率。
