Gjerset R A, Yeargin J, Volkman S K, Vila V, Arya J, Haas M
Cancer Center, University of California, San Diego, La Jolla 92093.
J Immunol. 1990 Nov 15;145(10):3497-501.
We have studied the phenotypic characteristics and growth properties of murine T lymphoma cell lines derived from primary x-ray-induced thymic lymphomas at the earliest stage at which they can be detected, and well before spreading to other organs has occurred. These cell lines serve as model systems for the earliest events in T cell lymphoma induction, before tumor cell progression and spreading to other organs. We find that primary x-ray-induced T cell lymphoma lines have phenotypic characteristics of thymic pre-T cells and show no proliferative response to any of the IL tested nor to other hematopoietic growth factors. However, they do proliferate in response to insulin-like growth factor I (IGF-I) and to a small autocrine peptide distinct from IGF-I, which we term lymphoma growth factor. One of the earliest lesions in T cell lymphoma induction may therefore be an inhibition of differentiation at one of several specific points. In its early stages, T lymphoma cell growth may be restricted to an environment where local concentrations of specific growth factors such as IGF-I or lymphoma growth factor are sufficiently high.
我们研究了源自原发性X射线诱导的胸腺淋巴瘤的小鼠T淋巴瘤细胞系的表型特征和生长特性，这些细胞系处于最早可检测到的阶段，且远在肿瘤扩散至其他器官之前。这些细胞系作为T细胞淋巴瘤诱导早期事件的模型系统，此时肿瘤细胞尚未进展并扩散至其他器官。我们发现，原发性X射线诱导的T细胞淋巴瘤细胞系具有胸腺前T细胞的表型特征，对所测试的任何白细胞介素及其他造血生长因子均无增殖反应。然而，它们对胰岛素样生长因子I（IGF-I）以及一种不同于IGF-I的小自分泌肽（我们称之为淋巴瘤生长因子）有增殖反应。因此，T细胞淋巴瘤诱导过程中最早出现的病变之一可能是在几个特定点之一处的分化抑制。在其早期阶段，T淋巴瘤细胞的生长可能局限于特定生长因子（如IGF-I或淋巴瘤生长因子）局部浓度足够高的环境中。
