Astellas Pharma Europe Ltd, Staines, Middlesex, United Kingdom.
Pediatr Infect Dis J. 2012 Jun;31(6):630-2. doi: 10.1097/INF.0b013e31824ab9b0.
Although micafungin pharmacokinetic values were comparable between younger (<5 years) and older children (≥5 years) with candidemia and invasive candidiasis, younger children had a lower peak plasma micafungin concentration, lower micafungin exposure and larger micafungin clearance. Half-life remained unchanged with repeated dosing. Metabolite plasma concentrations remained low in older children; however, metabolite M-5 concentrations were higher in younger children.
虽然在患有念珠菌血症和侵袭性念珠菌病的儿童中（<5 岁和≥5 岁），米卡芬净的药代动力学值具有可比性，但年龄较小的儿童的峰血浆米卡芬净浓度较低、米卡芬净暴露量较低且米卡芬净清除率较大。重复给药时半衰期保持不变。代谢产物的血浆浓度在年龄较大的儿童中仍然较低；然而，年龄较小的儿童中代谢产物 M-5 的浓度较高。
