Institute for Neuropathic Pain, Vespuccistraat 64-III, 1056 SN Amsterdam, The Netherlands.
Acupunct Med. 2012 Mar;30(1):53-5. doi: 10.1136/acupmed-2011-010119. Epub 2012 Feb 1.
Central neuropathic pain is a common debilitating symptom in patients with multiple sclerosis. Side effects of analgesics often limit reaching therapeutic dosages. In this case report, a 61-year-old woman with chronic central neuropathic pain due to multiple sclerosis is described. Acupuncture could only partly and temporarily reduce the pain. However, after adding the natural compound palmitoylethanolamide, a glial modulator and peroxisome proliferator-activated receptor-α agonist, pain reduction was more pronounced and the interval between acupuncture sessions could be increased. A multimodal stepped care approach is demonstrated, with acupuncture and palmitoylethanolamide both influencing non-neuronal cells, such as activated glial cells, which are key factors in the development and maintenance of neuropathic pain.
中枢神经性疼痛是多发性硬化症患者常见的致残症状。镇痛药的副作用常常限制了达到治疗剂量。在本病例报告中，描述了一位 61 岁的女性，她患有多发性硬化症引起的慢性中枢神经性疼痛。针灸只能部分且暂时缓解疼痛。然而，在添加天然化合物棕榈酸乙醇酰胺（一种神经胶质调节剂和过氧化物酶体增殖物激活受体-α激动剂）后，疼痛缓解更为明显，并且可以增加针灸治疗的间隔。展示了一种多模式阶梯式护理方法，针灸和棕榈酸乙醇酰胺都可以影响非神经元细胞，如激活的神经胶质细胞，这是非神经性疼痛发生和维持的关键因素。
