State University of New York Upstate Medical University, Syracuse, NY, USA.
J Infect Dis. 2012 Mar 15;205(6):906-13. doi: 10.1093/infdis/jir872. Epub 2012 Feb 1.
Infection with Epstein-Barr virus (EBV) early in life and repeated malaria exposure have been proposed as risk factors for endemic Burkitt lymphoma (eBL).
Infants were enrolled from 2 rural sites in Kenya: the Kisumu District, where malaria transmission is holoendemic and risk for eBL is high, and the Nandi District, where malaria transmission is limited and the risk for eBL is low. Blood samples were taken from infants through 2 years of age to measure EBV viral load, EBV antibodies, and malaria parasitemia.
We observed a significantly younger age at time of primary EBV infection in children from Kisumu compared with children from Nandi (mean age, 7.28 months [±0.33 SEM] in Kisumu vs 8.39 months [±0.26 SEM] in Nandi), with 35.3% of children in Kisumu infected before 6 months of age. To analyze how different predictors affected EBV viral load over time, we performed multilevel mixed modeling. This modeling revealed that residence in Kisumu and younger age at first EBV infection were significant predictors for having a higher EBV viral load throughout the period of observation.
Children from a region at high risk for eBL were infected very early in life with EBV, resulting in higher viral loads throughout infancy.
生活早期感染 Epstein-Barr 病毒（EBV）和反复疟疾暴露被认为是地方性 Burkitt 淋巴瘤（eBL）的危险因素。
从肯尼亚的两个农村地区招募婴儿：基苏木区，疟疾传播呈全流行，eBL 风险高；和 Nandi 区，疟疾传播有限，eBL 风险低。在 2 岁以下时，从婴儿身上采集血液样本以测量 EBV 病毒载量、EBV 抗体和疟疾寄生虫血症。
与来自 Nandi 的儿童相比，来自 Kisumu 的儿童在原发性 EBV 感染时的年龄明显更小（Kisumu 的平均年龄为 7.28 个月[±0.33 SEM]，而 Nandi 的平均年龄为 8.39 个月[±0.26 SEM]），有 35.3%的 Kisumu 儿童在 6 个月之前就已被感染。为了分析不同的预测因素如何随时间影响 EBV 病毒载量，我们进行了多层次混合建模。该模型表明，居住在 Kisumu 和首次 EBV 感染的年龄较小是整个观察期间 EBV 病毒载量较高的重要预测因素。
来自 eBL 高风险地区的儿童在生命早期就被 EBV 感染，导致整个婴儿期的病毒载量较高。
