Rao K R S Sambasiva, Nagabhushanam M V, Chowdary K P R
Achrya Nagarjuna University, Nagarjunanagar-522 510, Guntur, India.
Indian J Pharm Sci. 2011 Mar;73(2):243-7. doi: 10.4103/0250-474x.91575.
Solid dispersions of mefanamic acid with a water-soluble polymer polyvinyl pyrrolidine and a super disintegrant, primojel were prepared by common solvent and solvent evaporation methods employing methanol as the solvent. The dissolution rate and dissolution efficiency of the prepared solid dispersions were evaluated in comparison to the corresponding pure drug. Solid dispersions of mefenamic acid showed a marked enhancement in dissolution rate and dissolution efficiency. At 1:4 ratio of mefenamic acid-primojel a 2.61 fold increase in the dissolution rate of mefenamic acid was observed with solid dispersion. The solid dispersions in combined carriers gave much higher rates of dissolution than super disintegrants alone. Mefanamic acid-primojel-polyvinyl pyrrolidine (1:3.2:0.8) solid dispersion gave a 4.11 fold increase in the dissolution rate of mefenamic acid. Super disintegrants alone or in combination with polyvinyl pyrrolidine could be used to enhance the dissolution rate of mefenamic acid.
以甲醇为溶剂，采用共溶剂法和溶剂蒸发法制备了甲芬那酸与水溶性聚合物聚乙烯吡咯烷酮以及超级崩解剂优特奇的固体分散体。与相应的纯药物相比，对所制备的固体分散体的溶出速率和溶出效率进行了评估。甲芬那酸固体分散体的溶出速率和溶出效率显著提高。在甲芬那酸与优特奇比例为1:4时，观察到固体分散体中甲芬那酸的溶出速率提高了2.61倍。复合载体中的固体分散体比单独使用超级崩解剂的溶出速率高得多。甲芬那酸-优特奇-聚乙烯吡咯烷酮（1:3.2:0.8）固体分散体使甲芬那酸的溶出速率提高了4.11倍。单独使用超级崩解剂或与聚乙烯吡咯烷酮联合使用均可提高甲芬那酸的溶出速率。
