Hiura K, Yamada H, Yamaguchi T, Katoh O, Nagasawa Z
Clinical Laboratory, Saga Medical School.
Kansenshogaku Zasshi. 1990 Jul;64(7):866-70. doi: 10.11150/kansenshogakuzasshi1970.64.866.
Pasteurella multocide (P. multocida), a small gram-negative bacillus, has been known to be the causative agent of hemorrhagic septicemia in animals. P. multocida infection in human was reported as skin abscess and/or septicemia after an animal bit or scratch. Pulmonary infections of P. multocida have been developed in the patients with chronic pulmonary diseases such as bronchiectasis. In Japan, however, P. multocida respiratory tract infections are rare. In this report, a 80-year-old female with bronchiectasis was admitted on August, 1985. She had a productive cough, hemosputum, and a low grade fever. The chest X-P on admission showed an atelectasis of the left middle lobe and severe bronchiectatic changes of the left lower lobe. P. multocida was isolated from her sputa. The chemotherapy of CTM resulted in clinical improvement. On May 1988, she complained of a productive cough and a low grade fever again. P. multocida was isolated from the sputum on several occasions in significant numbers (1 x 10(8)/ml). Recently, the cases of the chronic respiratory diseases have been increasing. We think, P. multocida is important and should be considered as a pathogen in the care of chronic pulmonary diseases.
多杀巴斯德菌（P. multocida）是一种革兰氏阴性小杆菌，已知是动物出血性败血症的病原体。据报道，人类在被动物咬伤或抓伤后会感染多杀巴斯德菌，引发皮肤脓肿和/或败血症。患有支气管扩张等慢性肺部疾病的患者会出现多杀巴斯德菌肺部感染。然而，在日本，多杀巴斯德菌呼吸道感染较为罕见。在本报告中，一名80岁患有支气管扩张的女性于198年8月入院。她有咳痰、咯血和低热症状。入院时胸部X光显示左中叶肺不张和左下叶严重支气管扩张改变。从她的痰液中分离出了多杀巴斯德菌。使用头孢噻肟进行化疗后临床症状有所改善。1988年5月，她再次出现咳痰和低热症状。多次从痰液中分离出大量多杀巴斯德菌（1×10⁸/ml）。最近，慢性呼吸道疾病的病例一直在增加。我们认为，多杀巴斯德菌很重要，在慢性肺部疾病护理中应被视为病原体。
