Sueyama H
Department of Radiology, Faculty of Medicine, University of the Ryukyus.
Nihon Gan Chiryo Gakkai Shi. 1990 Aug 20;25(8):1599-607.
Eight patients with untreated squamous cell carcinoma of the esophagus accompanying distant metastases who were treated by one to five cycles of chemotherapy consisting of Cisplatin and 120 hour infusion of 5-Fluorouracil were reported. Two patients showed complete response (CR), four partial response (PR), one minor response, and one no response. High response rate of 75% (6 of 8) was obtained. Radiation therapy was then administered to six of the patients. After definitive treatment, CR was obtained in four, and PR in two of the cases. However, relapses were noted in all four of the CR cases, with four at distant sites, and one locally. Five of the eight patients (62.5%) survived one year and two survived three years (25%). Two patients could not receive radiotherapy because of uncontrollable lung metastases or death from duodenal ulcer. Although the follow-up period is still short, the combined treatment of radiation and pre-radiation chemotherapy appears to be an effective treatment, and has made a major impact upon survival time in cases of disseminated esophageal carcinoma.
报告了8例未经治疗的伴有远处转移的食管鳞状细胞癌患者，他们接受了由顺铂和持续120小时输注氟尿嘧啶组成的1至5个周期化疗。2例患者显示完全缓解（CR），4例部分缓解（PR），1例轻度缓解，1例无反应。获得了75%（8例中的6例）的高缓解率。然后对其中6例患者进行了放射治疗。在确定性治疗后，4例获得CR，2例获得PR。然而，所有4例CR病例均出现复发，4例为远处复发，1例为局部复发。8例患者中有5例（62.5%）存活1年，2例存活3年（25%）。2例患者因无法控制的肺转移或死于十二指肠溃疡而无法接受放疗。虽然随访期仍然较短，但放疗和放疗前化疗的联合治疗似乎是一种有效的治疗方法，并且对播散性食管癌患者的生存时间产生了重大影响。
