Department of Medicine, Division of Endocrinology, Gerontology, and Metabolism, Stanford University, Stanford, CA 94305, USA.
Cell. 2012 Feb 3;148(3):387-9. doi: 10.1016/j.cell.2012.01.032.
Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1α.
尽管白藜芦醇的健康益处已有充分的文献记载，但它的作用机制仍存在争议。特别是，白藜芦醇的直接分子靶标一直难以捉摸。Park 等人现在表明，白藜芦醇直接抑制 cAMP 依赖性磷酸二酯酶，引发一系列事件，这些事件集中在重要的能量感应代谢调节剂 AMPK、SIRT1 和 PGC-1α 上。
