Freitas A A, Moura V B L, Gonçalves S F, Rodrigues A A, Félix R M, Soares T P, Irusta V R C, Vinaud M C, Oliveira M A P, Lino R S
Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás (UFG), Rua 235, S/N, Qd 62, Lt AR1, Setor Universitário, CEP: 74605-050, Goiânia-GO, Brazil.
J Comp Pathol. 2012 Aug-Oct;147(2-3):267-74. doi: 10.1016/j.jcpa.2011.12.009. Epub 2012 Feb 3.
The larval stage of Taenia crassiceps has been used to study human cysticercosis as these larvae have antigenic similarity to the cysticerci of Taenia solium. The aim of this study was to evaluate the histopathological and immunological changes that followed the inoculation of T. crassiceps cysticerci into the subcutaneous tissue of C57BL/6 mice. Microscopically, granulomas formed of neutrophils and macrophages developed at the sites of inoculation. The serum concentration of the cytokine interferon (IFN)-γ increased throughout the course of infection, while the serum concentration of interleukin-4 increased during the period of transition from the initial phase (7-30 days postinoculation [dpi]) to the late phase (60-90 dpi) of infection. Destruction of the parasite therefore appears to be associated with an increase in IFN-γ, suggesting that a type 1 immune response is important in the control of the parasite.
粗头绦虫的幼虫阶段已被用于研究人类囊尾蚴病，因为这些幼虫与猪带绦虫的囊尾蚴具有抗原相似性。本研究的目的是评估将粗头绦虫囊尾蚴接种到C57BL/6小鼠皮下组织后所发生的组织病理学和免疫学变化。在显微镜下，接种部位形成了由中性粒细胞和巨噬细胞组成的肉芽肿。在整个感染过程中，细胞因子干扰素（IFN）-γ的血清浓度升高，而白细胞介素-4的血清浓度在感染从初始阶段（接种后7 - 30天[dpi]）过渡到后期阶段（60 - 90 dpi）期间升高。因此，寄生虫的破坏似乎与IFN-γ的增加有关，这表明1型免疫反应在控制寄生虫方面很重要。
