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[2000年至2009年期间马里的粟粒性肺结核]

[Miliary tuberculosis in Mali during the decade 2000-2009].

作者信息

Toloba Y, Diallo S, Maïga Y, Sissoko B F, Keïta B

机构信息

Service de pneumo-phtisiologie, CHU du point G, Bamako, Mali.

出版信息

Rev Pneumol Clin. 2012 Feb;68(1):17-22. doi: 10.1016/j.pneumo.2011.06.010. Epub 2011 Aug 25.

DOI:10.1016/j.pneumo.2011.06.010
PMID:22305133
Abstract

In order to describe the epidemio-clinical and evolutionary aspects of miliary tuberculosis (TB) in Mali, a retrospective study of 10 years (1 January 2000 to December 31, 2009) was conducted in the service of pneumo-phtisiology at the university hospital of point G. It concerned all patients with radiological images compatible with miliary TB, signs of bacillary impregnation, bacillus or not, treated with antituberculosis drugs. Of 3630 TB patients all forms recorded during the study period, 183 miliary were recorded (5%) including 117 men and 66 women. Young adults between 29-45 years were more represented (52%). The average diagnostic delay was 3.7 months. The symptomatology was dominated by the fever (100%), cough (90.1%) and asthenia (86.3%), anorexia (81.9%). The radiological images types of micronodular opacities were the most frequent in 147 cases (80.3%) against 36 cases of (19.7%) macronodular types. Bacteriological examination of sputum was negative in 139 patients (76%) and positive in 44 patients (24%). There was a statistically significant relationship between the presence of an excavation in Chest radiography and smear positivity (P<0.001). The clinical improvement observed (55.7%) depended on the time of the diagnosis (P<0.001). The serology HIV was positive at 29 patients on 124 tested. Also, in areas with high prevalence TB/HIV, any miliary fever in the absence of other obvious etiologies should undertake without delay TB proper treatment.

摘要

为描述马里粟粒性肺结核(TB)的流行病学临床特征及演变情况,在G点大学医院的肺痨科开展了一项为期10年(2000年1月1日至2009年12月31日)的回顾性研究。研究对象为所有经抗结核药物治疗、具有与粟粒性肺结核相符的放射影像且有或无细菌感染迹象的患者。在研究期间记录的3630例各类肺结核患者中,记录到183例粟粒性肺结核(5%),其中男性117例,女性66例。29至45岁的青壮年占比更高(52%)。平均诊断延迟为3.7个月。症状以发热(100%)、咳嗽(90.1%)、乏力(86.3%)、厌食(81.9%)为主。微小结节状阴影的放射影像类型最为常见,有147例(80.3%),而大结节状类型有36例(19.7%)。139例患者(76%)的痰细菌学检查为阴性,44例患者(24%)为阳性。胸部X线检查中出现空洞与涂片阳性之间存在统计学显著关联(P<0.001)。观察到的临床改善情况(55.7%)取决于诊断时间(P<0.001)。在124例接受检测的患者中,29例的血清学HIV检测呈阳性。此外,在结核病/艾滋病高流行地区,任何无其他明显病因的粟粒性发热患者应立即接受适当的结核病治疗。

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