Bayer Animal Health GmbH, Global Drug Discovery & Development, Building 6700, 51368 Leverkusen, Germany.
BMC Vet Res. 2012 Feb 6;8:14. doi: 10.1186/1746-6148-8-14.
Tolerability and efficacy of the intestinal phosphate binder Lantharenol® (lanthanum carbonate octahydrate) were tested in two prospective, randomized and negative controlled laboratory studies with healthy adult cats fed commercial maintenance diets non-restricted in phosphorus. In the first study, the maximal tolerated dose was determined. Starting from a dose of 0.125 g/kg body weight mixed with the daily feed ration, the dose of Lantharenol® was doubled every other week until signs of intolerability were observed (N=10 cats compared to 5 untreated controls). In the second study, the effects of feed supplementation for two weeks with approximately 2, 6, and 20% of the maximal tolerated dose on phosphorus excretion patterns and balance were assessed (N=8 cats per group).
Lantharenol® was found to be safe and well tolerated up to the dose of 1 g/kg bodyweight, corresponding to a concentration of 84 g Lantharenol®/kg complete feed, defined as dry matter with a standard moisture content of 12%. Feed supplementation for two weeks with approximately 2-20% of this dosage (i.e., 1.6, 4.8, and 16 g/kg complete feed) resulted in a shift from urinary to faecal phosphorus excretion. Apparent phosphorus digestibility was dose-dependently reduced compared to the control group fed with diet only (N=8).
The feed additive was well accepted and tolerated by all cats. Therefore, Lantharenol® presents a well tolerated and efficacious option to individually tailor restriction of dietary phosphorus as indicated, for instance, in feline chronic kidney disease.
在两项前瞻性、随机和阴性对照的实验室研究中，用商业维持饲料喂养非限制磷的健康成年猫，测试了肠道磷结合剂 Lantharenol®（八水合碳酸镧）的耐受性和疗效。在第一项研究中，确定了最大耐受剂量。从 0.125 g/kg 体重的剂量与每日饲料混合开始，每隔一周将 Lantharenol®的剂量增加一倍，直到出现不耐受迹象（N=10 只猫，与 5 只未治疗的对照猫相比）。在第二项研究中，评估了两周内用大约 2%、6%和 20%的最大耐受剂量补充饲料对磷排泄模式和平衡的影响（每组 N=8 只猫）。
发现 Lantharenol®在高达 1 g/kg 体重的剂量下是安全且耐受良好的，相当于 84 g Lantharenol®/kg 全价饲料，定义为标准水分含量为 12%的干物质。两周内用大约 2-20%的剂量（即 1.6、4.8 和 16 g/kg 全价饲料）补充饲料会导致磷从尿中转移到粪便中排泄。与仅用饮食喂养的对照组相比，表观磷消化率呈剂量依赖性降低（N=8）。
所有猫都很好地接受和耐受了这种饲料添加剂。因此，Lantharenol®是一种耐受良好且有效的选择，可以根据需要个体化限制饮食中的磷，例如在猫慢性肾病中。
