Cribier B
Clinique Dermatologique, Faculté de Médecine, Université de Strasbourg, Hôpitaux Universitaires de Strasbourg, 1 place de l'Hôpital, Strasbourg cedex, France.
Ann Dermatol Venereol. 2012 Jan;139 Suppl 1:S13-7. doi: 10.1016/S0151-9638(12)70103-5.
Several studies dealing with adherence of treatments for psoriasis have been published, using various methods, including questionnaires for self-reporting, interviews, counting/ weighting of unused medication and electronic measuring systems that record every cap unscrewing. Adherence to treatments is limited first by prescriptions not redeemed and then by under dosing in up to 95% of patients. The mean measured compliance is close to 50/60% and is lower than the self reported compliance in all studies. Adherence to topical treatment of psoriasis is limited by difficult self-application, greasy vehicle, number of applications, side effects or fear of side effects. Adherence decreases with time, although an increase in frequency of application is recorded before control visits. A better compliance increases the therapeutic effect. The motivation of dermatologists, the type and quality of the prescribed medicine and clear explanations are simple factors that contribute to increase adherence.
已经发表了几项关于银屑病治疗依从性的研究，采用了各种方法，包括自我报告问卷、访谈、未使用药物的计数/称重以及记录每次拧开瓶盖情况的电子测量系统。治疗依从性首先受到未取药处方的限制，其次高达95%的患者存在用药不足的情况。所有研究中，测量的平均依从性接近50%/60%，且低于自我报告的依从性。银屑病局部治疗的依从性受到自我涂抹困难、载体油腻、涂抹次数、副作用或对副作用的恐惧的限制。依从性随时间下降，尽管在复诊前记录到涂抹频率有所增加。更好的依从性可提高治疗效果。皮肤科医生的积极性、所开药物的类型和质量以及清晰的解释是有助于提高依从性的简单因素。
