山芝麻树皮提取物对环磷酰胺诱导的小鼠遗传毒性和氧化应激的影响。
Effect of Buchanania lanzan Spreng. bark extract on cyclophosphamide induced genotoxicity and oxidative stress in mice.
机构信息
SLT Institute of Pharmceutical Sciences, Guru Ghasidas Vishwavidyalaya, Central University, Bilaspur, Chhattisgarh, India.
出版信息
Asian Pac J Trop Med. 2012 Mar;5(3):187-91. doi: 10.1016/S1995-7645(12)60022-4.
OBJECTIVE
To elucidate the effect of ethanolic extract of Buchanania lanzan Spreng. (B. lanan) bark against cyclophosphamide induced genotoxicity and oxidative stress in mice.
METHODS
The prevalence of micronuclei in bone marrow, the extent of lipid peroxidation, reduced glutathione and the status of the antioxidant enzymes, superoxide dismutase and catalase in liver of mice were used as intermediate biomarkers for chemoprotection. Lipid peroxidation and associated compromised antioxidant defenses in cyclophosphamide treated mice were observed in the liver.
RESULTS
Pre-treatment with B. lanzan 250, 500 and 1,000 mg/kg, p.o., daily for 7 days significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems.
CONCLUSIONS
These results point out the presence of chemopreventive phytoconstituents in the crude extract offering protection against cyclophosphamide induced genotoxicity and oxidative stress in mice.
目的
阐明樟科植物树皮乙醇提取物（B. lanan）对环磷酰胺诱导的小鼠遗传毒性和氧化应激的影响。
方法
骨髓微核的发生率、脂质过氧化程度、还原型谷胱甘肽以及超氧化物歧化酶和过氧化氢酶在肝中的状态被用作化学保护的中间生物标志物。在环磷酰胺处理的小鼠的肝中观察到脂质过氧化和相关的抗氧化防御功能受损。
结果
B. lanzan 250、500 和 1000mg/kg，每天口服，预处理 7 天，可显著降低染色体损伤和脂质过氧化，同时改变抗氧化剂和解毒系统。
结论
这些结果表明，粗提物中存在化学预防植物成分，可提供对环磷酰胺诱导的小鼠遗传毒性和氧化应激的保护。
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