老年人的免疫参数：与有氧能力、肌肉力量和情绪状态的相关性。

Immunological parameters in elderly women: correlations with aerobic power, muscle strength and mood state.

机构信息

Department of Experimental Pathophysiology, Medical School of the University of Sao Paulo, FMUSP, Brazil.

出版信息

Brain Behav Immun. 2012 May;26(4):597-606. doi: 10.1016/j.bbi.2012.01.012. Epub 2012 Jan 28.

DOI:10.1016/j.bbi.2012.01.012

PMID:22306455

Abstract

PURPOSE

Our objective was to relate immunological data for healthy but sedentary elderly women to aerobic power, strength, and mood state.

METHODS

We measured peak aerobic power and one-repetition maximum strength along with mood (depression and fatigue), quality of life and carbohydrate intake on 42 women aged 60-77 years. Standard immunological techniques determined natural killer cell count and cytotoxic activity (NKCA), proliferative responses to phytohemaglutinin and OKT(3), various lymphocyte subpopulations (CD3(+), CD3(-)CD19(+), CD56(+), CD4(+), CD8(+), CD56(dim) and CD56(bright)), and markers of activation, maturation, down-regulation and susceptibility to apoptosis (CD25(+), CD28(+), CD45RA(+), CD45RO(+), CD69(+), CD95(+), HLA-DR(+)).

RESULTS

Correlations of immune parameters with aerobic power and strength were very similar for absolute and relative immunological data. In the group as a whole, the only correlation with aerobic power was -0.35 (relative CD4(+)CD69(+) count), but in subjects with values <22.6 mL kg(-1)min(-1) correlations ranged from -0.57 (relative CD4(+)CD45RO(+)) to 0.92 (absolute CD56(dim)HLA-DR(+)). In terms of muscle strength, univariate correlation coefficients ranged from -0.34 (relative and absolute CD3(+)CD4(+)CD8(+)) to +0.48 (absolute CD3(+)HLA-DR(+)) and +0.50 (absolute CD8(+)CD45RA(+)CD45RO(+)). Neither NKCA nor lymphocyte proliferation were correlated with aerobic power or muscle strength. Although mood state and quality of life can sometimes be influenced by an individual's fitness level, our multivariate analyses suggested that depression, fatigue and quality of life were more important determinants of immune profile than our fitness measures.

CONCLUSIONS

Psychological changes associated with aging may have a substantial adverse effect upon the immune system, and immunological function may be enhanced more by addressing these issues than by focusing upon aerobic or resistance training.

摘要

目的

本研究旨在探讨健康但久坐的老年女性的免疫数据与有氧能力、力量和情绪状态之间的关系。

方法

我们对 42 名年龄在 60-77 岁的女性进行了峰值有氧能力和一次重复最大力量测试，同时还评估了她们的情绪（抑郁和疲劳）、生活质量和碳水化合物摄入量。采用标准免疫技术检测自然杀伤细胞计数和细胞毒性活性（NKCA）、植物血凝素和 OKT(3)的增殖反应、各种淋巴细胞亚群（CD3(+)、CD3(-)CD19(+)、CD56(+)、CD4(+)、CD8(+)、CD56(dim)和 CD56(bright)）以及激活、成熟、下调和易凋亡的标志物（CD25(+)、CD28(+)、CD45RA(+)、CD45RO(+)、CD69(+)、CD95(+)、HLA-DR(+)）。

结果

绝对和相对免疫数据与有氧能力和力量的相关性非常相似。在整个研究组中，与有氧能力唯一相关的是 -0.35（相对 CD4(+)CD69(+)计数），但在有氧能力值<22.6 mL kg(-1)min(-1)的受试者中，相关性范围从 -0.57（相对 CD4(+)CD45RO(+)）到 0.92（绝对 CD56(dim)HLA-DR(+)）。就肌肉力量而言，单变量相关系数范围从 -0.34（相对和绝对 CD3(+)CD4(+)CD8(+)）到 +0.48（绝对 CD3(+)HLA-DR(+））和 +0.50（绝对 CD8(+)CD45RA(+)CD45RO(+)）。NKCA 或淋巴细胞增殖均与有氧能力或肌肉力量无关。尽管情绪状态和生活质量有时会受到个体健康水平的影响，但我们的多元分析表明，与我们的健康测量相比，抑郁、疲劳和生活质量是免疫特征的更重要决定因素。