[两例炎症性肠病中硫嘌呤诱发的急性胰腺炎]
[Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease].
作者信息
Nishikawa Jun, Kudo Takahiko, Miyazaki Takako, Mihara Hiroshi, Ueda Akira, Ando Takayuki, Kajiura Shinya, Fujinami Haruka, Ogawa Kohei, Hosokawa Ayumu, Sugiyama Toshiro
机构信息
Department of Gastroenterology and Hematology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
出版信息
Nihon Shokakibyo Gakkai Zasshi. 2012 Feb;109(2):224-30.
Thiopurine drugs have been widely used in the treatment of inflammatory bowel disease. However, their use is limited by adverse effect that can lead to cessation of therapy. We report 2 cases of thiopurine-induced acute pancreatitis in patients with inflammatory bowel disease. Both patients complained of abdominal pain, showed elevated pancreatic enzymes, and swollen pancreases on computed tomography. The patients' signs and symptoms resolved uneventfully after withdrawal of the thiopurine drugs. Although the mechanism of thiopurine-induced pancreatitis remains unclear, close monitoring and early recognition of acute pancreatitis is important in the management of new thiopurine users.
硫嘌呤类药物已广泛用于治疗炎症性肠病。然而，其使用受到不良反应的限制，这些不良反应可能导致治疗中断。我们报告了2例炎症性肠病患者发生硫嘌呤诱导的急性胰腺炎。两名患者均主诉腹痛，计算机断层扫描显示胰腺酶升高和胰腺肿大。停用硫嘌呤类药物后，患者的体征和症状顺利缓解。虽然硫嘌呤诱导胰腺炎的机制尚不清楚，但在管理新使用硫嘌呤的患者时，密切监测和早期识别急性胰腺炎很重要。
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