Department of Breast Medical Oncology, MD Anderson CancerCenter, Houston, USA.
Cancer Prev Res (Phila). 2012 Feb;5(2):147-9. doi: 10.1158/1940-6207.CAPR-11-0579.
A growing body of evidence is now connecting neuroendocrine mediators of the stress response to cancer biology. Al-Wadei and colleagues report a study in this issue of the journal (beginning on page 189) that provides a new piece of this evidence, adding the inhibitory neurotransmitter γ-aminobutyric acid to this intricate pathway. Their mouse model study supports the hypothesis that stress mediators contribute to lung cancer progression and that known inhibitors of the stress pathway might block such effects, thus adding to the impetus for studying cancer prevention strategies targeting the stress pathway.
越来越多的证据将应激反应的神经内分泌介质与癌症生物学联系起来。Al-Wadei 及其同事在本期杂志上（从第 189 页开始）报告了一项研究，为这一复杂途径提供了新的证据，即添加抑制性神经递质 γ-氨基丁酸。他们的小鼠模型研究支持这样一种假设，即应激介质有助于肺癌的进展，而应激途径的已知抑制剂可能阻断这种效应，从而为研究针对应激途径的癌症预防策略增添了动力。
