第二、三、四头颈肿瘤。生存逐渐下降。
Second, third, and fourth head and neck tumors. A progressive decrease in survival.
机构信息
Department of Otorhinolaryngology, Institut d'Investigacions Biomèdiques Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
出版信息
Head Neck. 2012 Dec;34(12):1716-9. doi: 10.1002/hed.21977. Epub 2012 Feb 6.
BACKGROUND
Patients with a first head and neck carcinoma have a high risk of successive neoplasms, many of which appear again in the head and neck. Second head and neck tumors have a poorer prognosis than first tumors, but data about the prognosis of third and fourth tumors in the head and neck are lacking.
METHODS
We carried out a retrospective study of 4298 patients with a primary head and neck carcinoma. Survival and the characteristics of the first tumor, second tumor, and any successive tumors in the head and neck were analyzed.
RESULTS
Second and successive tumors showed a tendency to appear more frequently in the oral cavity and oropharynx and had a lower stage than that of index tumors. Five-year survival rates after a first, second, third, and fourth tumors in the head and neck were 67.6%, 56.1%, 45.0%, and 32.1%, respectively.
CONCLUSION
Survival decreased progressively with every new head and neck tumor.
背景
患有头颈部原发性肿瘤的患者有很高的罹患继发性肿瘤的风险，其中许多肿瘤会再次出现在头颈部。与原发性肿瘤相比，头颈部的第二原发性肿瘤预后较差，但关于头颈部第三和第四原发性肿瘤的预后数据尚缺乏。
方法
我们对 4298 例头颈部原发性肿瘤患者进行了回顾性研究。分析了生存情况以及头颈部第一、第二和任何继发性肿瘤的特征。
结果
第二和继发性肿瘤更倾向于出现在口腔和口咽，且分期比原发性肿瘤低。头颈部第一、第二、第三和第四原发性肿瘤的 5 年生存率分别为 67.6%、56.1%、45.0%和 32.1%。
结论
随着新发头颈部肿瘤的增加，生存率逐渐降低。
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