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肝内胆管细胞癌原发肿瘤切除 6 年后结肠转移致肠梗阻 1 例报告

Intestinal obstruction caused by colonic metastasis from intrahepatic cholangiocarcinoma 6 years after removal of the primary tumor: report of a case.

机构信息

Division of Transplantation, Reconstruction, and Endoscopic Surgery, Tohoku University Hospital, 1-1 Seiryou-machi, Aoba-ku, Sendai, 980-8574, Japan.

出版信息

Surg Today. 2012 Aug;42(8):797-800. doi: 10.1007/s00595-012-0138-4. Epub 2012 Feb 4.

DOI:10.1007/s00595-012-0138-4
PMID:22307905
Abstract

We report a case of intestinal obstruction caused by metastasis that manifested 6 years after surgery for intrahepatic cholangiocarcinoma (ICC). The patient, a 57-year-old man, had undergone resection of the hepatic left lobe, Spiegel lobe, and extrahepatic bile duct, following which histopathological examination had confirmed the diagnosis of ICC and that the resection margins were free from disease. There had been no signs of recurrence until an increase in the CA19-9 level was detected 6 years later. Colonoscopy revealed an ulcer-like lesion and stenosis at the level of the hepatic flexure. The patient was subsequently admitted to our hospital with abdominal pain and underwent right hemicolectomy with partial resection of hepatic segment V. Based on the immunohistological finding that the expression pattern of cytokeratins and mucins was consistent with ICC origin rather than colon cancer origin, we diagnosed colon metastasis from ICC.

摘要

我们报告了一例术后 6 年因肝内胆管细胞癌(ICC)转移导致肠梗阻的病例。患者为 57 岁男性,曾行左半肝、Spiegel 叶及肝外胆管切除术,术后组织病理学检查诊断为 ICC,且切缘无肿瘤累及。无复发迹象,直到 6 年后 CA19-9 水平升高。结肠镜检查显示肝曲处存在溃疡样病变和狭窄。患者随后因腹痛入院,行右半结肠切除术并切除肝段 V 部分。基于免疫组化发现细胞角蛋白和黏蛋白的表达模式符合 ICC 起源而非结肠癌起源,我们诊断为 ICC 结肠转移。

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