Lavrinchuk B Ia, Kotenko K A, Golembiovs'ka S L, Matseliukh B P
Mikrobiol Z. 2011 Nov-Dec;73(6):31-5.
Eight highly productive UV-induced mutants of Streptomyces globisporus 1912 with high biosynthesis of landomycin E were isolated, their isolation frequency being 2 x 10(-3). Mutants 1-1, 1-4-1, 1-1y, 1-2y, 4-1, 1-2 produced 175-187.5 mg of landomycine E and 1-1b, 4-1-1 and 1-3--80-100 mg per 1 liter of soybean agar after 48 hours of cultivation The mutant 4-1-1 had the highest antibiotic activity and middle level of landomycin E production.
分离出了8株高产的紫外线诱导的球孢链霉菌1912突变体，它们能高效生物合成地霉素E，其分离频率为2×10⁻³。突变体1-1、1-4-1、1-1y、1-2y、4-1、1-2在1升大豆琼脂培养基上培养48小时后可产生175 - 187.5毫克地霉素E，而突变体1-1b、4-1-1和1-3 - 80 - 100毫克。突变体4-1-1具有最高的抗生素活性和中等水平的地霉素E产量。
