Oncogenetics Team, The Institute of Cancer Research, Sutton, Surrey, UK.
J Intern Med. 2012 Apr;271(4):353-65. doi: 10.1111/j.1365-2796.2012.02511.x.
Prostate cancer is the commonest cancer in the developed world. There is an inherited component to this disease as shown in familial and twin studies. However, the discovery of these variants has been difficult. The emergence of genome-wide association studies has led to the identification of over 46 susceptibility loci. Their clinical utility to predict risk, response to treatment, or treatment toxicity, remains undefined. Large consortia are needed to achieve adequate statistical power to answer these genetic-clinical and genetic-epidemiological questions. International collaborations are currently underway to link genetic with clinical/epidemiological data to develop risk prediction models, which could direct screening and treatment programs.
在发达国家，前列腺癌是最常见的癌症。家族和双胞胎研究表明，这种疾病具有遗传因素。然而，这些变体的发现一直很困难。全基因组关联研究的出现导致了超过 46 个易感性位点的鉴定。它们在预测风险、治疗反应或治疗毒性方面的临床应用尚未确定。需要大型联盟来获得足够的统计能力来回答这些遗传-临床和遗传-流行病学问题。目前正在进行国际合作，将遗传与临床/流行病学数据联系起来，以开发风险预测模型，从而指导筛查和治疗计划。
