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纳洛酮与2-溴-α-麦角隐亭或可乐定相互作用对正常人血清中黄体生成素、卵泡刺激素、催乳素及促甲状腺激素水平影响的研究

A study on the effects of interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone levels in normal man serum.

作者信息

Agnati L F, Benfenati F, Cortelli P, D'alessandro R, Ghisoli E, Zampa G A

出版信息

Neurosci Lett. 1979 May;12(2-3):307-11. doi: 10.1016/0304-3940(79)96080-4.

DOI:10.1016/0304-3940(79)96080-4
PMID:223091
Abstract

The effects of 2-Br-alpha-ergocryptine (2.5 mg/osM), clonidine (50 microgram, intramuscularly) and naloxone (0.4 mg, intramuscularly) as well as the interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone (LH) follicle-stimulating hormone (FSH), prolactin (PL) and thyroid-stimulating hormone (TSH) serum levels in normal man have been studied. 2-Br-alpha-ergocryptine and clonidine clearly reduce and naloxone tends to reduce PL serum levels. TSH levels are lowered by naloxone as well by clonidine plus naloxone. The results obtained point also to a possible different pattern of LH and FSH secretion after naloxone, that is after opiate receptor blockade. The clonidine effects on PL secretion are discussed in the frame of a possible adrenergic control of the release of this hormone.

摘要

研究了2-溴-α-麦角隐亭（2.5毫克/口服）、可乐定（50微克，肌肉注射）和纳洛酮（0.4毫克，肌肉注射）以及纳洛酮与2-溴-α-麦角隐亭或可乐定之间的相互作用对正常男性血清促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PL）和促甲状腺激素（TSH）水平的影响。2-溴-α-麦角隐亭和可乐定明显降低血清PL水平，纳洛酮也有降低血清PL水平的趋势。纳洛酮以及可乐定加纳洛酮均可降低TSH水平。所得结果还表明，纳洛酮作用后，即阿片受体阻断后，LH和FSH的分泌模式可能不同。在该激素释放可能受肾上腺素能控制的框架内，讨论了可乐定对PL分泌的影响。

相似文献

1
A study on the effects of interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone levels in normal man serum.纳洛酮与2-溴-α-麦角隐亭或可乐定相互作用对正常人血清中黄体生成素、卵泡刺激素、催乳素及促甲状腺激素水平影响的研究
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2
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引用本文的文献

1
A possible role of endogenous opioids in the control of prolactin and luteinizing-hormone secretion in the human.内源性阿片肽在人体催乳素和促黄体生成素分泌调控中的可能作用。
J Endocrinol Invest. 1981 Jan-Mar;4(1):31-6. doi: 10.1007/BF03349410.
2
Neuroendocrine control of basal insulin secretion in man: a study with bromocriptine, clonidine and naloxone.人基础胰岛素分泌的神经内分泌控制：一项使用溴隐亭、可乐定和纳洛酮的研究。
J Endocrinol Invest. 1981 Oct-Dec;4(4):423-9. doi: 10.1007/BF03348306.
3
Drug-induced changes in prolactin secretion. Clinical implications.
药物引起的催乳素分泌变化。临床意义。
Med Toxicol Adverse Drug Exp. 1988 Nov-Dec;3(6):463-98. doi: 10.1007/BF03259897.