Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México.
Pharmacol Biochem Behav. 2012 May;101(3):336-41. doi: 10.1016/j.pbb.2012.01.021. Epub 2012 Jan 28.
Sexually sluggish (SS) male rats represent a small proportion of animals that take a long time to ejaculate, or sometimes they do not ejaculate, when tested on repeated occasions with sexually receptive females. The current study was done in order to evaluate whether chronic estradiol (E(2)) or testosterone (T) treatment could induce consistent ejaculatory behavior in these male rats. Those males that displayed sexual behavior but did not ejaculate in at least four of five tests were classified as SS and included in the present experiment. They were implanted subcutaneously with Silastic capsules that were empty or filled with E(2) or T. Starting one week after the implant, subjects were tested weekly with sexually receptive females for seven consecutive weeks. At the end of the experiment all subjects were weighed and sacrificed to weigh the accessory sex glands. The results showed that SS males implanted with an empty or T-filled capsule remained as such; they displayed mounts and intromissions but not a consistent pattern of ejaculation despite the twelve weeks of testing (5 screening tests and 7 with the corresponding implant). In contrast, the percentage of SS males implanted with an E(2) capsule that displayed the ejaculatory pattern was significantly reduced. Subjects treated with E(2) also displayed a higher number of mounts than the empty capsule group during several weeks of testing. At the end of the experiment the weights of the body, testicles, epididymis, seminal vesicles, and prostate of the SS male rats chronically treated with E(2) were lower than those of the empty or T capsule groups. In addition, male rats with a T implant showed lower testicular weight than the empty capsule group. These results suggest that the lack of ejaculation patter in SS male rats is not due to estrogenic or androgenic alteration.
性反应迟钝（SS）雄性大鼠在与性接受雌性动物反复测试时，需要很长时间才能射精，或者有时甚至不射精。本研究旨在评估慢性雌二醇（E（2））或睾酮（T）治疗是否能诱导这些雄性大鼠出现一致的射精行为。那些在至少四次五次测试中表现出性行为但未射精的雄性大鼠被归类为 SS，并被纳入本实验。他们被皮下植入装有 E（2）或 T 的硅橡胶胶囊。植入后一周，将实验对象每周与性接受雌性动物进行测试，连续七周。实验结束时，所有实验对象均称重并处死，以测量附属性腺的重量。结果表明，植入空胶囊或 T 填充胶囊的 SS 雄性大鼠仍然如此；尽管进行了十二周的测试（包括五次筛选测试和七次对应植入测试），它们仍表现出交配和插入行为，但没有一致的射精模式。相比之下，植入 E（2）胶囊的 SS 雄性大鼠中表现出射精模式的比例明显降低。在数周的测试中，用 E（2）治疗的实验对象表现出的交配次数也多于空胶囊组。实验结束时，慢性接受 E（2）治疗的 SS 雄性大鼠的体重、睾丸、附睾、精囊和前列腺的重量均低于空胶囊或 T 胶囊组。此外，植入 T 胶囊的雄性大鼠的睾丸重量低于空胶囊组。这些结果表明，SS 雄性大鼠缺乏射精模式并非由于雌激素或雄激素的改变所致。
