São Paulo State University - UNESP, Physical Education Department, Av: 24-A, 1515 Bela Vista, CEP: 13506-900 Rio Claro - São Paulo - Brazil.
Diabetol Metab Syndr. 2012 Feb 6;4(1):5. doi: 10.1186/1758-5996-4-5.
This study aimed to examine the effects of intermittent and continuous swimming training on muscle protein metabolism in neonatal alloxan-administered rats.
Wistar rats were used and divided into six groups: sedentary alloxan (SA), sedentary control (SC), continuous trained alloxan (CA), intermittent trained alloxan (IA), continuous trained control (CC) and intermittent trained control (IC). Alloxan (250 mg/kg body weight) was injected into newborn rats at 6 days of age. The continuous training protocol consisted of 12 weeks of swimming training in individual cylinder tanks while supporting a load that was 5% of body weight; uninterrupted swimming for 1 h/day, five days a week. The intermittent training protocol consisted of 12 weeks of swimming training in individual cylinder tanks while supporting a load that was 15% of body weight; 30 s of activity interrupted by 30 s of rest for a total of 20 min/day, five days a week.
At 28 days, the alloxan animals displayed higher glycemia after glucose overload than the control animals. No differences in insulinemia among the groups were detected. At 120 days, no differences in serum albumin and total protein among the groups were observed. Compared to the other groups, DNA concentrations were higher in the alloxan animals that were subjected to continuous training, whereas the DNA/protein ratio was higher in the alloxan animals that were subjected to intermittent training.
It was concluded that continuous and intermittent training sessions were effective in altering muscle growth by hyperplasia and hypertrophy, respectively, in alloxan-administered animals.
本研究旨在探讨间歇和连续游泳训练对新生链脲佐菌素处理大鼠肌肉蛋白质代谢的影响。
使用 Wistar 大鼠，将其分为六组：安静的链脲佐菌素（SA）、安静的对照（SC）、连续训练的链脲佐菌素（CA）、间歇训练的链脲佐菌素（IA）、连续训练的对照（CC）和间歇训练的对照（IC）。在新生大鼠 6 天时，向其注射链脲佐菌素（250mg/kg 体重）。连续训练方案包括 12 周的个体圆柱缸游泳训练，同时支撑 5%体重的负荷；每天游泳 1 小时，每周 5 天。间歇训练方案包括 12 周的个体圆柱缸游泳训练，同时支撑 15%体重的负荷；30 秒的活动后休息 30 秒，每天共 20 分钟，每周 5 天。
在 28 天时，与对照组相比，经葡萄糖超负荷处理的链脲佐菌素动物的血糖升高。各组间胰岛素血症无差异。在 120 天时，各组间血清白蛋白和总蛋白无差异。与其他组相比，连续训练的链脲佐菌素动物的 DNA 浓度较高，而间歇训练的链脲佐菌素动物的 DNA/蛋白质比值较高。
连续和间歇训练方案可有效改变肌肉生长，分别通过增生和肥大使链脲佐菌素处理的动物的肌肉生长。
