微妙的平衡：调整白细胞介素-2免疫疗法。 - Suppr

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A delicate balance: tweaking IL-2 immunotherapy.

出版信息

Nat Med. 2012 Feb 6;18(2):208-9. doi: 10.1038/nm0212-208.

DOI:10.1038/nm0212-208

PMID:22310686

Abstract

摘要

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Interleukin-2 and regulatory T cells in graft-versus-host disease.白细胞介素 2 与移植物抗宿主病中的调节性 T 细胞。

N Engl J Med. 2011 Dec 1;365(22):2055-66. doi: 10.1056/NEJMoa1108188.

Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells.雷帕霉素和白细胞介素-2 可减少致命性急性移植物抗宿主病，同时增加供体来源的 CD4+CD25+Foxp3+调节性 T 细胞的扩增。

Blood. 2011 Aug 25;118(8):2342-50. doi: 10.1182/blood-2010-10-313684. Epub 2011 Jul 6.

Interleukin-2 receptor signaling: at the interface between tolerance and immunity.白细胞介素-2 受体信号转导：在耐受与免疫之间的界面。

Immunity. 2010 Aug 27;33(2):153-65. doi: 10.1016/j.immuni.2010.08.004.

In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.利用白细胞介素-2-单克隆抗体复合物在体内扩增调节性T细胞：诱导对实验性自身免疫性脑脊髓炎的抗性以及在无免疫抑制情况下对胰岛同种异体移植物的长期接受。

J Exp Med. 2009 Apr 13;206(4):751-60. doi: 10.1084/jem.20082824. Epub 2009 Mar 30.

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