代谢综合征与帕金森病相关痴呆：年龄和高血压的影响
Metabolic syndrome and dementia associated with Parkinson's disease: impact of age and hypertension.
作者信息
Schelp Arthur Oscar, Mendes-Chiloff Cristiane Lara, Bazan Rodrigo, Paduan Vanessa Cristina, Pioltini Ana Beatriz Maringolo
机构信息
Department of Neurology, Psychology and Psychiatry, Botucatu Medical School, São Paulo State University "Júlio de Mesquita Filho", Botucatu, SP, Brazil.
出版信息
Arq Neuropsiquiatr. 2012 Feb;70(2):114-8. doi: 10.1590/s0004-282x2012000200008.
OBJECTIVE
To determine correlations between age and metabolic disorders in Parkinson's disease (PD) patients.
METHODS
This observational cross-sectional study included brief tests for dementia and the Mattis test. Signals of metabolic syndrome were evaluated.
RESULTS
There was no significant effect from the presence of hypertension (OR=2.36 for patients under 65 years old and OR=0.64 for patients over 65), diabetes or hypercholesterolemia regarding occurrences of dementia associated with PD (24% of the patients). The study demonstrated that each year of age increased the estimated risk of dementia in PD patients by 9% (OR=1.09; 95%CI: 1.01-1.17).
CONCLUSION
There was no evidence to correlate the presence of metabolic syndrome with the risk of dementia that was associated with PD. The study confirmed that dementia in PD is age dependent and not related to disease duration.
目的
确定帕金森病（PD）患者年龄与代谢紊乱之间的相关性。
方法
这项观察性横断面研究包括简易痴呆测试和马蒂斯测试。评估代谢综合征信号。
结果
高血压（65岁以下患者的比值比为2.36，65岁以上患者的比值比为0.64）、糖尿病或高胆固醇血症的存在对与PD相关的痴呆症发生率（24%的患者）没有显著影响。该研究表明，年龄每增加一岁，PD患者患痴呆症的估计风险增加9%（比值比=1.09；95%置信区间：1.01-1.17）。
结论
没有证据表明代谢综合征的存在与与PD相关的痴呆症风险相关。该研究证实，PD中的痴呆症与年龄有关，与病程无关。
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