Norwegian centre for movement disorders, Stavanger University Hospital, Helse Stavanger, Norway.
Mov Disord. 2011 Apr;26(5):824-9. doi: 10.1002/mds.23525. Epub 2011 Mar 21.
There may be a relationship between cognitive impairment and visual hallucinations (VHs) in patients with Parkinson's disease (PD). The objective of this study was to compare the cognitive profile of hallucinating vs. nonhallucinating patients with Parkinson's disease dementia (PDD).
The cognitive profile of 86 PDD patients with hallucinations was compared with that of a carefully matched PDD group without hallucinations, all drawn from the baseline assessments of the EXPRESS study with rivastigmine. Logistic regression analysis was employed to identify cognitive measures that have an independent relationship with presence of hallucinations.
Worse choice reaction time was the only independent predictor of hallucinations in the logistic regression. A further analysis of the reaction time tasks showed that response selection deficit as opposed to stimulus discrimination deficit was the main difference between the groups.
These results indicate that attentional control is an important cognitive correlate of VHs in patients with PDD.
认知障碍与帕金森病（PD）患者的幻视（VH）之间可能存在关联。本研究的目的是比较有和无帕金森病痴呆（PDD）幻觉的患者的认知特征。
对来自 rivastigmine 的 EXPRESS 研究基线评估的 86 例有幻觉的 PDD 患者的认知特征与精心匹配的无幻觉 PDD 组进行比较。采用逻辑回归分析确定与幻觉存在有独立关系的认知测量。
较差的选择反应时间是逻辑回归中幻觉的唯一独立预测因子。对反应时间任务的进一步分析表明，与刺激辨别缺陷相比，反应选择缺陷是两组之间的主要差异。
这些结果表明，注意力控制是 PDD 患者 VH 的一个重要认知相关因素。
