Moroz V V, Smelaia T V, Salnikova L E, Golubev A M, Rubanovich A V
Vestn Ross Akad Med Nauk. 2011(11):12-6.
The study included 243 patients with acute community-acquired pneumonia and 173 healthy subjects. The following candidate loci were used to investigate genetic variability: 3 sites of CYP1A1, GSTM1, GSTT1, GSTP1, ACE gene of the rennin-angiotensin system, chemokine receptor gene CCR5. Enhanced predisposition to pneumonia was shown to be characteristic of homozygotes in deletion at the ACE locus (OR = 1.8; p = 0.013), carriers of normal alleles of the GSTM1 locus (OR = 1.7; p = 0.010), and homozygotes in allele 606T of the CYP1A1 gene (OR = 1.6; p = 0.020).
该研究纳入了243例急性社区获得性肺炎患者和173名健康受试者。使用以下候选基因座来研究基因变异性：细胞色素P450 1A1（CYP1A1）的3个位点、谷胱甘肽S-转移酶M1（GSTM1）、谷胱甘肽S-转移酶T1（GSTT1）、谷胱甘肽S-转移酶P1（GSTP1）、肾素-血管紧张素系统的血管紧张素转换酶（ACE）基因、趋化因子受体基因CCR5。研究表明，ACE基因座缺失的纯合子（比值比=1.8；p=0.013）、GSTM1基因座正常等位基因携带者（比值比=1.7；p=0.010）以及CYP1A1基因606T等位基因的纯合子（比值比=1.6；p=
