Eldaba Ahmed A, Amr Yasser M
Department of Anesthesia, Tanta University Hospital, Tanta, Egypt.
Anaesth Intensive Care. 2012 Jan;40(1):150-3. doi: 10.1177/0310057X1204000118.
This study evaluates the effect of prophylactic granisetron on the incidence of postoperative shivering after spinal anaesthesia in children. Eighty children, American Society of Anesthesiologists physical status I to II and aged two to five years were scheduled for surgery of the lower limb under spinal anaesthesia. The children were randomised to receive 10 µg/kg granisetron diluted in 10 ml saline 0.9% intravenously (group 1, n=40) or placebo (10 ml 0.9% saline, group 2, n=40) to be given over five minutes just before spinal puncture. Shivering, core temperature and the levels of motor and sensory block were assessed. No patients shivered in group 1. However, six patients shivered in Group 2 (P=0.025). There were no significant differences in the other measured variables between the groups. Granisetron is an effective agent to prevent shivering after spinal anaesthesia in children from two to five years of age.
本研究评估预防性使用格拉司琼对儿童脊髓麻醉后术后寒战发生率的影响。八十名美国麻醉医师协会身体状况I至II级、年龄在2至5岁的儿童计划接受脊髓麻醉下的下肢手术。将儿童随机分为两组，一组静脉注射用10ml 0.9%生理盐水稀释的10µg/kg格拉司琼（第1组，n = 40），另一组注射安慰剂（10ml 0.9%生理盐水，第2组，n = 40），在脊髓穿刺前5分钟内给药。评估寒战、核心体温以及运动和感觉阻滞水平。第1组无患者发生寒战。然而，第2组有6例患者发生寒战（P = 0.025）。两组之间其他测量变量无显著差异。格拉司琼是预防2至5岁儿童脊髓麻醉后寒战的有效药物。
