Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Eur J Pharmacol. 2012 Apr 5;680(1-3):41-8. doi: 10.1016/j.ejphar.2012.01.025. Epub 2012 Jan 31.
Chronic cerebral hypoperfusion, induced by permanent occlusion of bilateral common carotid arteries (2VO), is related to neurological disorders and contributes to cognitive decline. Chrysin (5,7-dihydroxyflavone) is an important member of the flavonoid family. The aim of this study is to investigate the effects of chrysin on cognitive deficits and brain damage in this rat 2VO model. At 52days after ligation, the escape latency in Morris water maze was significantly increased in rats subjected to 2VO, the neuronal damage was also increased accompanied by a large proliferation in glial fibrillary acidic protein (GFAP) immunoreactivity with marked white matter lesions, and neuronal cell apoptosis, all of which were significantly alleviated by long treatment of chrysin (30mg/kg). Biochemical examinations revealed that chrysin decreased lipid peroxide, reduced the increased activities of superoxide dismutase, and attenuated the decreased activities of glutathione peroxidase in 2VO rats. The results suggest that chrysin may have therapeutic potential for the treatment of neurodegeneration and dementia caused by decreased cerebral blood flow, which is most likely related, at least in part, to its anti-inflammatory and antioxidant properties.
慢性脑灌注不足，由双侧颈总动脉永久性闭塞（2VO）引起，与神经紊乱有关，并导致认知能力下降。白杨素（5,7-二羟基黄酮）是黄酮类家族的重要成员。本研究旨在探讨白杨素对该大鼠 2VO 模型认知缺陷和脑损伤的影响。在结扎后 52 天，2VO 大鼠在 Morris 水迷宫中的逃逸潜伏期明显延长，神经元损伤也增加，伴随着胶质纤维酸性蛋白（GFAP）免疫反应性的大量增殖和明显的白质病变，以及神经元细胞凋亡，所有这些都被白杨素（30mg/kg）的长期治疗显著缓解。生化检查显示，白杨素降低了脂质过氧化物，降低了超氧化物歧化酶活性的增加，并减轻了 2VO 大鼠谷胱甘肽过氧化物酶活性的降低。结果表明，白杨素可能具有治疗因脑血流减少引起的神经退行性变和痴呆的潜力，这与其抗炎和抗氧化特性有关，至少部分是相关的。
