Prasad Kavita, Wahner-Roedler Dietlind, Cha Stephen, Sood Amit
Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Altern Ther Health Med. 2011 Nov-Dec;17(6):36-42.
Patients' unwillingness to participate in clinical research is one of the main challenges that researchers face today. In Complementary and Alternative Medicine (CAM) research, a pertinent yet understudied question is the attitude of potential participants toward clinical trials that test CAM interventions.
To assess patients' attitudes and preferences regarding participation in clinical trials which test CAM rather than conventional treatments.
A 78-question, pencil-and-paper survey was conducted in collaboration with the Survey Research Center located in the Division of Biomedical Statistics and Informatics in the Department of Health Sciences Research at Mayo Clinic in Rochester, Minnesota.
The study took place at Mayo Clinic, an academic medical center for tertiary care in Rochester, Minnesota, USA.
Participants were patients undergoing a general medical evaluation at the Division of General Internal Medicine in the Department of Internal Medicine at Mayo Clinic.
The researchers designed a cross-sectional, point-of-care survey. The study coordinator approached patients and invited them to participate.
The study summarized the data for categorical variables, identifying numbers of participants and percentages and comparing two proportions using the Fisher exact test.
Out of 485 patients asked to participate, 400 (82%) completed the survey. Respondents were equally as interested in participating in clinical trials testing CAM as they were in trials testing conventional treatments (79% vs 69%, P = .09). For all participants, 107 (27%) were in favor of participating in CAM clinical trials and 118 (30%) were in favor of participating in conventional clinical trials.
Respondents were interested equally in participating in clinical trials testing CAM vs conventional treatments.
患者不愿参与临床研究是研究人员如今面临的主要挑战之一。在补充和替代医学（CAM）研究中，一个相关但研究不足的问题是潜在参与者对测试CAM干预措施的临床试验的态度。
评估患者对于参与测试CAM而非传统治疗的临床试验的态度和偏好。
与位于明尼苏达州罗切斯特市梅奥诊所健康科学研究部生物医学统计与信息学部门的调查研究中心合作，开展了一项有78个问题的纸笔调查。
该研究在美国明尼苏达州罗切斯特市的梅奥诊所进行，这是一家提供三级医疗服务的学术医疗中心。
参与者是在梅奥诊所内科普通内科部门接受综合医学评估的患者。
研究人员设计了一项横断面即时护理调查。研究协调员接触患者并邀请他们参与。
该研究总结了分类变量的数据，确定参与者的数量和百分比，并使用Fisher精确检验比较两个比例。
在被邀请参与的485名患者中，400名（82%）完成了调查。受访者对参与测试CAM的临床试验和测试传统治疗的临床试验同样感兴趣（79%对69%，P = 0.09）。对于所有参与者，107名（27%）赞成参与CAM临床试验，118名（30%）赞成参与传统临床试验。
受访者对参与测试CAM与传统治疗的临床试验同样感兴趣。
