Bøgwald Kjell Petter, Rudberg Ida, Tanum Lars, Refsum Helge
Seksjon for psykiatrisk forskning og undervisning, Diakonhjemmet Sykehus, Norway.
Tidsskr Nor Laegeforen. 2012 Feb 7;132(3):288-91. doi: 10.4045/tidsskr.10.1317.
The dose recommendations in the Norwegian Pharmaceutical Product Compendium (Felleskatalogen) are not gender-specific, despite evidence of gender-dependent differences in the metabolism of a number of drugs. The purpose of this study was to investigate the extent to which age and gender influence the prescription and serum concentration of psychotropic drugs.
The prescribed doses and serum concentrations of antidepressant, antipsychotic and antiepileptic drugs were studied in relation to age and gender in 1533 patients.
Elderly women (≥ 65 years) were given somewhat lower doses of antidepressant drugs, but they had significantly higher serum concentrations than younger patients of either gender. Antidepressant drugs were prescribed in fairly high doses in the study population; the median number of defined daily doses was 1.5.
The study suggests that when prescribing drugs, Norwegian physicians do not take sufficient account of the effect of age and gender on the pharmacokinetics of antidepressant drugs.
尽管有证据表明多种药物的代谢存在性别差异，但挪威药品手册（《通用目录》）中的剂量推荐并非针对特定性别。本研究的目的是调查年龄和性别对精神药物处方及血清浓度的影响程度。
对1533例患者的抗抑郁药、抗精神病药和抗癫痫药的处方剂量及血清浓度进行了与年龄和性别的相关性研究。
老年女性（≥65岁）服用的抗抑郁药剂量略低，但她们的血清浓度显著高于任何性别的年轻患者。研究人群中抗抑郁药的处方剂量相当高；限定日剂量的中位数为1.5。
该研究表明，挪威医生在开药时没有充分考虑年龄和性别对抗抑郁药药代动力学的影响。
