Tucker B A, Karamsadkar S S, Khan Wasim S, Pastides P
University College, London Medical School, London, UK.
J Stem Cells. 2010;5(4):155-66.
The therapeutic use of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been applied to many different tissue types that are vulnerable to sports injuries. Avenues of treatment include direct injection of BM-MSCs into the defect, however although minimally invasive, research has highlighted flaws which have been improved upon with the use of scaffolds. BM-MSCs have been applied via many different scaffold types, for example PLGA, collagen gel and coral each with advantages and disadvantages of which can be improved through further research. As a cell source for tissue engineering, BM-MSCs are ideal due to the minimal invasion of aspiration, high in vitro proliferation rate and the ability to maintain their differentiating capacity. The vast majority of these studies are at the small animal stage and therefore further work using larger animal models, and ideally humans is required.
骨髓间充质干细胞（BM-MSCs）的治疗用途已应用于许多易受运动损伤影响的不同组织类型。治疗途径包括将BM-MSCs直接注射到缺损处，然而，尽管这种方法微创，但研究已突出了其缺陷，而使用支架可对这些缺陷加以改进。BM-MSCs已通过许多不同类型的支架进行应用，例如聚乳酸-羟基乙酸共聚物（PLGA）、胶原凝胶和珊瑚，每种支架都有优缺点，可通过进一步研究加以改进。作为组织工程的细胞来源，BM-MSCs因其抽吸侵入性极小、体外增殖率高以及能够维持其分化能力而非常理想。这些研究绝大多数处于小动物阶段，因此需要使用更大动物模型进行进一步研究，理想情况下是开展人体研究。
