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2010年西孟加拉邦 Jalpaiguri 区医院采用国家治疗方案管理蛇咬伤病例——一项回顾性研究。

Management of snakebite cases by national treatment protocol at Jalpaiguri District Hospital in West Bengal in the year 2010--a retrospective study.

作者信息

Ghosh Manab Kumar

机构信息

Department of Tropical Medicine, School of Tropical Medicine, Kolkata 700073.

出版信息

J Indian Med Assoc. 2011 Aug;109(8):553-4, 559-60.

PMID:22315862
Abstract

Snakebite remains a public health problem in India, occurring most frequently in the summer and rainy seasons. Bites are maximal in lower limbs. Victims are typically male and between 17 and 27 years of age. Children and the elderly have higher mortality. The worst affected states are Kerala, Maharashtra, Tamil Nadu, Orissa, Assam and West Bengal. There was no uniform guideline for treatment of snakebite cases. The five common venomous Indian snakes biting humans are common cobra, krait, Russell's viper, saw scaled viper and the hump nose pit viper. Seventy per cent of all snakebites are non-venomous. Even in bites by venomous snakes, envenomation occurs in only 50% of cases. Immobilisation is much more important than tight ligature, which may cause gangrene. Only a minority need antivenom, which is expensive, short in supply and may cause severe reaction. Antivenom treatment is recommended on the basis of local and systemic signs and symptoms and 20 minutes whole blood clotting test (20WBCT). Delay in starting AVS treatment is the main cause of mortality and morbidity. Skin test is of no value. But antivenom should not be used unless specifically indicated. The "Do it RIGHT" approach of national treatment protocol indicates the initial steps to be taken before reaching a hospital or primary healthcare facility. And it resulted in a 66% decline in the amount of ASV administration and an absolute reduction of mortality by 24%. However first aid treatment of the bitten limb/area with broad-spectrum antibiotics, injection tetanus antitoxin and Supportive treatment with blood transfusion, ventilatory support, anticholinesterase and peritoneal dialysis may also be required.

摘要

蛇咬伤在印度仍然是一个公共卫生问题,在夏季和雨季最为频发。下肢被咬的情况最为常见。受害者通常为17至27岁的男性。儿童和老年人的死亡率更高。受影响最严重的邦是喀拉拉邦、马哈拉施特拉邦、泰米尔纳德邦、奥里萨邦、阿萨姆邦和西孟加拉邦。对于蛇咬伤病例的治疗没有统一的指导方针。印度五种常见的咬人毒蛇是眼镜蛇、金环蛇、罗素蝰蛇、锯鳞蝰蛇和尖吻蝮。所有蛇咬伤中有70%是非毒蛇咬伤。即使是被毒蛇咬伤,也只有50%的病例会发生中毒。固定比紧扎更为重要,紧扎可能会导致坏疽。只有少数人需要抗蛇毒血清,而抗蛇毒血清价格昂贵、供应短缺且可能会引起严重反应。根据局部和全身的体征及症状以及20分钟全血凝固试验(20WBCT)来推荐使用抗蛇毒血清治疗。开始抗蛇毒血清治疗的延迟是死亡率和发病率的主要原因。皮肤试验没有价值。但除非有明确指征,否则不应使用抗蛇毒血清。国家治疗方案的“正确处理”方法指明了在到达医院或初级卫生保健机构之前应采取的初始步骤。这使得抗蛇毒血清的使用量下降了66%,死亡率绝对降低了24%。然而,被咬肢体/部位可能还需要用广谱抗生素进行急救治疗、注射破伤风抗毒素,以及通过输血、通气支持、抗胆碱酯酶和腹膜透析进行支持治疗。

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