通过（3,5）-硫𬭩-烯环化反应立体选择性合成取代的四氢噻喃。
Diastereoselective synthesis of substituted tetrahydrothiopyrans via (3,5)-thionium-ene cyclization reaction.
机构信息
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
出版信息
J Org Chem. 2012 Mar 2;77(5):2508-12. doi: 10.1021/jo2023944. Epub 2012 Feb 17.
PMID:22316166
Abstract
Tetrahydrothiopyrans have been efficiently synthesized in good yields with excellent diastereoselectivity from aldehydes and substituted 5-methylhex-4-ene-1-thiol via (3,5)-thionium-ene cyclization reaction mediated by boron trifluoride etherate.
摘要
四氢噻喃类化合物可以通过三氟化硼乙醚介导的（3,5）-硫翁-烯环化反应，从醛和取代的 5-甲基己-4-烯-1-硫醇出发，以高产率和优异的非对映选择性合成。
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