Montefiori D C, Robinson W E, Hirsch V M, Modliszewski A, Mitchell W M, Johnson P R
Department of Pathology, Vanderbilt University, School of Medicine, Nashville, TN.
J Med Primatol. 1990;19(3-4):269-78.
Plasma from four rhesus macaques (Macaca mulatta), of which two were experimentally infected with the simian immunodeficiency virus (SIV) isolate SIVmac251, one with isolate SIVsmF236, and another with a SIVsmF236 molecular clone, SIVsmH-4, enhanced SIVmac infection of MT-2 cells. In addition to SIV-positive plasma, infection-enhancement required complement, CD4, and CR2. Titers of infection-enhancing antibodies appeared to correlate with disease progression. The MT-2/SIVmac251 system should be useful in future studies of complement-mediated, antibody-dependent enhancement of macaque and sooty mangabey SIV isolates.
来自四只恒河猴（猕猴）的血浆，其中两只经实验感染了猿猴免疫缺陷病毒（SIV）毒株SIVmac251，一只感染了毒株SIVsmF236，另一只感染了SIVsmF236分子克隆SIVsmH-4，这些血浆增强了MT-2细胞对SIVmac的感染。除了SIV阳性血浆外，感染增强还需要补体、CD4和CR2。感染增强抗体的滴度似乎与疾病进展相关。MT-2/SIVmac251系统在未来关于补体介导的、抗体依赖性增强猕猴和黑冠白眉猴SIV毒株的研究中应会有用。
