Department of Otorhinolaryngology Head and Neck Surgery, Interdisciplinary Centre for Vertigo and Balance Disorders (IFB-LMU), Grosshadern Medical Centre, University of Munich, Munich, Germany.
Am J Otolaryngol. 2012 Sep-Oct;33(5):533-7. doi: 10.1016/j.amjoto.2011.12.004. Epub 2012 Feb 6.
The aim of this study was to assess whether gadolinium-based contrast agent influences short-term hearing function in patients with Ménière's disease undergoing intratympanically enhanced inner-ear magnetic resonance imaging.
This is a prospective cohort study.
This study was conducted a tertiary referral university hospital, ENT department.
In this study, 21 adult patients with definite, unilateral Ménière's disease were included. According to the criteria of the Committee on Hearing and Equilibrium, all patients were in stage 1 or 2 of the disease, with largely preserved hearing function.
All patients underwent clinical and audiologic testing before and 24 hours after intratympanic application of gadolinium-based contrast agent. The effects of the contrast medium on the hearing function were assessed by analysis of frequency thresholds, pure-tone average from 500 Hz to 3 kHz, and speech audiometry.
Pure-tone average and single-frequency thresholds in audiometry showed no statistically significant difference after the application of intratympanic gadolinium-based contrast agent. Furthermore, speech audiometry scores remained stable after the application of the contrast agent.
This study did not demonstrate clinically significant short-term effects of intratympanic application of gadolinium-based contrast agent on hearing function in patients with Ménière's disease in initial stages.
本研究旨在评估鼓室内增强内耳磁共振成像中钆基造影剂是否会影响梅尼埃病患者的短期听力功能。
这是一项前瞻性队列研究。
本研究在一家三级转诊大学医院的耳鼻喉科进行。
本研究纳入了 21 例确诊、单侧梅尼埃病的成年患者。根据听力和平衡委员会的标准，所有患者均处于疾病的 1 期或 2 期，听力功能基本正常。
所有患者在鼓室内应用钆基造影剂前后均进行了临床和听力测试。通过分析频率阈值、500 Hz 至 3 kHz 的纯音平均听阈和言语测听来评估造影剂对听力功能的影响。
本研究未发现鼓室内应用钆基造影剂对早期梅尼埃病患者的听力功能有明显的短期临床影响。
