Borys D J, Setzer S C, Ling L J, Reisdorf J J, Day L C, Krenzelok E P
Hennepin Regional Poison Center, Minneapolis, MN 55415.
J Toxicol Clin Toxicol. 1990;28(3):331-40. doi: 10.3109/15563659008994434.
Fluoxetine (Prozac) is a new antidepressant, first marketed in the United States in January 1988. Only limited toxicologic information during a fluoxetine overdose is available. The goal of this prospective multi-center study was to develop a toxicity profile of initial signs and symptoms observed in fluoxetine overdose. A standardized data collection form was used on all patients ingesting fluoxetine as reported to four poison centers. Information obtained included age, dose, co-ingested drugs, presenting symptoms, vital signs, EKG abnormalities and lab values. Of the 127 cases of acute fluoxetine overdose collected, 106 cases met the criteria of the study. Of these, 69/106 ingested other drugs, including ethanol and 37/106 ingested fluoxetine alone. Of the latter group, the amounts ingested ranged from 20 to 1500 mg. It was observed that 48.6% (18/37) remained asymptomatic, 16.2% (7/37) were sleepy, 24.3% (9/37) had a sinus tachycardia (of 100 beats per minute or greater), and 8.1% (3/37) had a diastolic pressure over 100 mm Hg. Data collection is ongoing. Based upon our initial experience, fluoxetine in overdose appears to be relatively benign.
氟西汀（百忧解）是一种新型抗抑郁药，于1988年1月在美国首次上市。关于氟西汀过量服用时的毒理学信息有限。这项前瞻性多中心研究的目的是确定氟西汀过量服用时最初出现的体征和症状的毒性特征。对向四个中毒控制中心报告的所有服用氟西汀的患者使用标准化数据收集表。获得的信息包括年龄、剂量、同时服用的药物、出现的症状、生命体征、心电图异常和实验室检查值。在收集的127例急性氟西汀过量服用病例中，106例符合研究标准。其中，69/106例同时服用了其他药物，包括乙醇，37/106例仅服用了氟西汀。在后一组中，服用量为20至1500毫克。观察到48.6%（18/37）无症状，16.2%（7/37）嗜睡，24.3%（9/37）窦性心动过速（每分钟100次或以上），8.1%（3/37）舒张压超过100毫米汞柱。数据收集仍在进行中。根据我们的初步经验，过量服用氟西汀似乎相对无害。
