猪睾丸表达基因11（Tex11）的特征分析。
Characterization of the porcine testis-expressed gene 11 (Tex11).
作者信息
Tang Lin, Zeng Wenxian, Clark Robert K, Dobrinski Ina
机构信息
Department of Comparative Biology & Experimental Medicine; Faculty of Veterinary Medicine; University of Calgary; Calgary, AB Canada.
College of Animal Science & Technology; Northwest A & F University; Shaanxi, China.
出版信息
Spermatogenesis. 2011 Apr-Jun;1(2):147-151. doi: 10.4161/spmg.1.2.16680.
Testis expressed gene 11 () is essential for meiosis and male fertility in the mouse. Currently, little is known about the control of spermatogenesis in non-rodent animal models such as pigs. Here, we characterized the sequence and expression profile of the porcine gene. We showed that the porcine is an X-linked gene that is exclusively expressed in germ cells in the adult pig testis. The expression of porcine is correlated with the onset of meiosis and the expression pattern is highly conserved between the homologs in pig and mouse. The DNA sequence analysis and the estimated molecular weight also suggested a high level of homology across species. As the mouse proved to be essential for male fertility, the important biological function during meiosis is likely conserved in the porcine .
睾丸表达基因11（）对小鼠减数分裂和雄性生育能力至关重要。目前，对于猪等非啮齿动物模型中精子发生的调控知之甚少。在此，我们对猪基因的序列和表达谱进行了特征分析。我们发现猪基因是一个X连锁基因，在成年猪睾丸的生殖细胞中特异性表达。猪基因的表达与减数分裂的开始相关，并且其表达模式在猪和小鼠的同源物之间高度保守。DNA序列分析和估计的分子量也表明跨物种存在高度同源性。由于小鼠基因已被证明对雄性生育能力至关重要，因此减数分裂期间的重要生物学功能可能在猪基因中保守。
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