Department of Nephrology, Ankara, Turkey.
Amyloid. 2012 Mar;19(1):28-32. doi: 10.3109/13506129.2012.654530. Epub 2012 Feb 10.
The aim of this study was to evaluate the relationship of local intrarenal renin angiotensin system (RAS) with proteinuria in patients with renal AA amyloidosis.
Thirty-two patients with renal AA amyloidosis (19 male, mean age: 45 ± 13 years) and sixteen healthy controls (5 male, mean age: 32 ± 5 years) were included in this study. Spot urine samples were obtained to measure urinary angiotensinogen (AGT) using human AGT-ELISA, urinary creatinine and protein levels. Logarithmic transformations of urinary AGT-creatinine ratio log(UAGT/Ucre) and urinary protein-to-creatinine ratio (UPCR) were done to obtain the normal distributions of these parameters.
Log(UAGT/UCre) was significantly higher in patients compared with the controls (1.88 ± 0.92 µg/g vs. 1.25 ± 0.70 µg/g; p = 0.023). Importantly a significantly positive correlation was found between log(UAGT/Ucre) and logUPCR in patients (r = 0.595, p = 0.006).
Urinary AGT levels are higher in renal AA amyloidosis patients than in controls. Also, there is a significant positive correlation between urinary AGT and proteinuria in renal AA amyloidosis.
本研究旨在评估肾 AA 淀粉样变性患者局部肾素-血管紧张素系统 (RAS) 与蛋白尿的关系。
本研究纳入了 32 例肾 AA 淀粉样变性患者（19 名男性，平均年龄：45±13 岁）和 16 名健康对照者（5 名男性，平均年龄：32±5 岁）。收集尿标本，采用人 AGT-ELISA 法检测尿血管紧张素原 (AGT)，并测定尿肌酐和蛋白水平。对尿 AGT-肌酐比值 (log[UAGT/Ucre]) 和尿蛋白/肌酐比值 (UPCR) 进行对数转换，以获得这些参数的正态分布。
与对照组相比，患者的 log(UAGT/Ucre) 明显升高 (1.88±0.92 µg/g 比 1.25±0.70 µg/g；p=0.023)。重要的是，患者的 log(UAGT/Ucre) 与 logUPCR 之间存在显著的正相关关系 (r=0.595，p=0.006)。
肾 AA 淀粉样变性患者的尿 AGT 水平高于对照组。此外，肾 AA 淀粉样变性患者的尿 AGT 与蛋白尿之间存在显著的正相关关系。
