Institute of Physiology (230), Dept. Membrane Physiology, University of Hohenheim, Garbenstr. 30, 70593 Stuttgart, Germany.
Curr Med Chem. 2012;19(2):298-302. doi: 10.2174/092986712803414178.
Spreading Depression is the underlying patho physiological mechanism for the neurological symptoms of migraine aura and is thought to play a major role in triggering migraine. Therefore it seems reasonable to use the Spreading Depression as a pharmacological tool for anti migraine drugs. Drugs that are able to alter parameters of Spreading Depression should also influence appearance and course of migraine attacks. Concerning the classification on the different mechanisms of drug action, especially the retinal Spreading Depression is useful, due to the separation of vascular and neuronal effects. In this study we investigated substances from different classes of common anti migraine drugs on different parameters of the retinal spreading depression. The results are discussed according to the classification of the drug.
扩散性抑制是偏头痛先兆神经症状的潜在病理生理机制，被认为在偏头痛发作中起主要作用。因此，将扩散性抑制作为抗偏头痛药物的药理学工具似乎是合理的。能够改变扩散性抑制参数的药物也应该影响偏头痛发作的表现和过程。关于药物作用的不同机制的分类，特别是视网膜扩散性抑制是有用的，因为它可以分离血管和神经元的作用。在这项研究中，我们研究了来自不同类别的常见抗偏头痛药物的物质对视网膜扩散性抑制的不同参数的影响。根据药物的分类对结果进行了讨论。
