Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden.
Contact Dermatitis. 2012 Mar;66(3):137-9. doi: 10.1111/j.1600-0536.2011.02041.x.
Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers.
Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT.
5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT.
In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.
了解致敏和激发阈值以及接触性皮炎激发的时-量关系对于为消费者提供安全的产品非常重要。
由于之前使用丁香酚进行的研究在重复开放性应用研究（ROAT）中显示出阴性结果，因此我们希望进行更高浓度（最大允许浓度）和更长 ROAT 的 ROAT。
对 5 名之前对丁香酚呈阳性反应的志愿者进行了研究。他们使用四种不同的溶液进行了最长 4 周的 ROAT 测试。结果。在 ROAT 中，有 4 名志愿者对丁香酚的最大浓度产生了反应。
在对丁香酚过敏的患者中，使用最大允许浓度的丁香酚并进行延长的 ROAT（4 周），则明显存在诱发变应性接触性皮炎的风险。
