School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
J Microencapsul. 2012;29(5):463-74. doi: 10.3109/02652048.2012.658444. Epub 2012 Feb 10.
An experimental and theoretical methodology is proposed to calculate the permeability of microcapsules that contain a core of oil-based active ingredient. Theoretical analysis is performed considering the polydispersity of the measurable capsule size, which allows the estimation of the permeability polydispersity via three different methods. The models proposed were applied in order to determine the permeability of melamine-formaldehyde microcapsules with hexyl salicylate as core oil. Release experiments were performed with four different co-solvents (ethanol, propan-1-ol, propan-2-ol and 1,3-butanediol) of different concentration. Permeability values were found to be constant, despite a two order magnitude of difference in the solubility concentrations.
提出了一种实验和理论方法来计算含有油基活性成分芯材的微胶囊的渗透率。理论分析考虑了可测量的胶囊尺寸的多分散性，这允许通过三种不同的方法估计渗透率的多分散性。所提出的模型被应用于确定以己基水杨酸为芯油的三聚氰胺-甲醛微胶囊的渗透率。释放实验使用了四种不同浓度的不同共溶剂（乙醇、丙-1-醇、丙-2-醇和 1,3-丁二醇）进行。尽管在溶解度浓度上存在两个数量级的差异，但渗透率值被发现是恒定的。
