Neuromuscular Division, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA,
J Headache Pain. 2012 Apr;13(3):255-7. doi: 10.1007/s10194-012-0421-1. Epub 2012 Feb 10.
Burning mouth syndrome has been reported as being more common in Parkinson's disease patients than the general population. While the pathophysiology is unclear, decreased dopamine levels and dopamine dysregulation are hypothesized to play a role. We report a patient with Parkinson's disease who developed burning mouth syndrome with carbidopa/levodopa. Our patient had resolution of burning mouth symptoms when carbidopa/levodopa was replaced with a dopamine agonist. Based on our patient's clinical course, in conjunction with earlier studies assessing the relationship between burning mouth syndrome and Parkinson's disease, we discuss a potential role for dopamine in burning mouth syndrome in Parkinson's disease.
据报道，帕金森病患者中口腔烧灼感的发生率高于普通人群。虽然其病理生理学机制尚不清楚，但多巴胺水平下降和多巴胺失调被认为起一定作用。我们报告了一例帕金森病患者，在使用卡比多巴/左旋多巴后出现口腔烧灼感。当卡比多巴/左旋多巴被多巴胺激动剂替代后，患者的口腔烧灼感症状得到缓解。基于患者的临床病程，并结合早期研究评估口腔烧灼感与帕金森病之间的关系，我们讨论了多巴胺在帕金森病口腔烧灼感中的潜在作用。
