乳糜泻相关麸质 T 细胞表位的命名和分类，这些表位受 HLA-DQ 分子限制。
Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules.
机构信息
Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway.
出版信息
Immunogenetics. 2012 Jun;64(6):455-60. doi: 10.1007/s00251-012-0599-z. Epub 2012 Feb 10.
Abstract
Celiac disease is caused by an abnormal intestinal T-cell response to gluten proteins of wheat, barley and rye. Over the last few years, a number of gluten T-cell epitopes restricted by celiac disease associated HLA-DQ molecules have been characterized. In this work, we give an overview of these epitopes and suggest a comprehensive, new nomenclature.
摘要
乳糜泻是由机体对小麦、大麦和黑麦中的麸质蛋白产生异常的肠道 T 细胞应答引起的。在过去的几年中，许多与乳糜泻相关的 HLA-DQ 分子限制性的麸质 T 细胞表位已被鉴定。在这项工作中，我们对这些表位进行了概述，并提出了一个全面的、新的命名法。
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本文引用的文献
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Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.高密度基因分型鉴定和定位了乳糜泻中的多个常见和罕见变异关联信号。
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Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer. gluten 特异性 T 细胞在 HLA-DQ8 和 HLA-DQ2α/DQ8β 转二聚体之间发生交叉反应。
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Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells.在小鼠中，脾脏 1 型调节性 T 细胞维持对摄入的脱酰胺麦胶的耐受性。
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