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Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules.乳糜泻相关麸质 T 细胞表位的命名和分类，这些表位受 HLA-DQ 分子限制。
Immunogenetics. 2012 Jun;64(6):455-60. doi: 10.1007/s00251-012-0599-z. Epub 2012 Feb 10.
2
Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4 T cells.更新 2020 年：细胞毒性 T 淋巴细胞识别的与乳糜泻相关的麸质表位的命名和列表。
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4
Two novel HLA-DQ2.5-restricted gluten T cell epitopes in the DQ2.5-glia-γ4 epitope family.DQ2.5-神经胶质γ4 表位家族中的两个新的 HLA-DQ2.5 限制性谷氨酰胺 T 细胞表位。
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7
From an understanding of etiopathogenesis to novel therapies-what is new in the treatment of celiac disease?从乳糜泻的病因病理学到新型疗法——乳糜泻治疗有哪些新进展？
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本文引用的文献

1
T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease.HLA-DQ2.2 阳性的乳糜泻患者的 T 细胞对 gluten 的反应揭示了麸质敏感性疾病中肽-MHC 稳定性的要求。
Gastroenterology. 2012 Mar;142(3):552-61. doi: 10.1053/j.gastro.2011.11.021. Epub 2011 Nov 19.
2
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.高密度基因分型鉴定和定位了乳糜泻中的多个常见和罕见变异关联信号。
Nat Genet. 2011 Nov 6;43(12):1193-201. doi: 10.1038/ng.998.
3
Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer. gluten 特异性 T 细胞在 HLA-DQ8 和 HLA-DQ2α/DQ8β 转二聚体之间发生交叉反应。
J Immunol. 2011 Nov 15;187(10):5123-9. doi: 10.4049/jimmunol.1101179. Epub 2011 Oct 17.
4
Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells.在小鼠中，脾脏 1 型调节性 T 细胞维持对摄入的脱酰胺麦胶的耐受性。
Gastroenterology. 2011 Aug;141(2):610-20, 620.e1-2. doi: 10.1053/j.gastro.2011.04.048. Epub 2011 Apr 28.
5
The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes.转谷氨酰胺酶 2 在复杂的小麦面筋消化物中的首选底物是含有乳糜泻 T 细胞表位的肽片段。
PLoS One. 2010 Nov 19;5(11):e14056. doi: 10.1371/journal.pone.0014056.
6
Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.在乳糜泻中全面、定量绘制麸质中的 T 细胞表位。
Sci Transl Med. 2010 Jul 21;2(41):41ra51. doi: 10.1126/scitranslmed.3001012.
7
Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation.与HLA - DQ2.5或HLA - DQ2.2相关的乳糜泻风险差异与持续的麸质抗原呈递有关。
Nat Immunol. 2009 Oct;10(10):1096-101. doi: 10.1038/ni.1780. Epub 2009 Aug 30.
8
Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells.在表达特异性抗麦醇溶蛋白CD4 + T细胞的人源化HLA - DR3 - DQ2转基因小鼠中对乳糜泻的抗性。
J Immunol. 2009 Jun 15;182(12):7440-50. doi: 10.4049/jimmunol.0900233.
9
Intestinal T cell responses to gluten peptides are largely heterogeneous: implications for a peptide-based therapy in celiac disease.肠道T细胞对麸质肽的反应在很大程度上是异质性的：对基于肽的乳糜泻治疗的启示。
J Immunol. 2009 Apr 1;182(7):4158-66. doi: 10.4049/jimmunol.0803181.
10
A quantitative analysis of transglutaminase 2-mediated deamidation of gluten peptides: implications for the T-cell response in celiac disease.转谷氨酰胺酶2介导的麸质肽脱酰胺作用的定量分析：对乳糜泻中T细胞反应的影响
J Proteome Res. 2009 Apr;8(4):1748-55. doi: 10.1021/pr800960n.

乳糜泻相关麸质 T 细胞表位的命名和分类，这些表位受 HLA-DQ 分子限制。

Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules.

机构信息

Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway.

出版信息

Immunogenetics. 2012 Jun;64(6):455-60. doi: 10.1007/s00251-012-0599-z. Epub 2012 Feb 10.

DOI:10.1007/s00251-012-0599-z
PMID:22322673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3349865/
Abstract

Celiac disease is caused by an abnormal intestinal T-cell response to gluten proteins of wheat, barley and rye. Over the last few years, a number of gluten T-cell epitopes restricted by celiac disease associated HLA-DQ molecules have been characterized. In this work, we give an overview of these epitopes and suggest a comprehensive, new nomenclature.

摘要

乳糜泻是由机体对小麦、大麦和黑麦中的麸质蛋白产生异常的肠道 T 细胞应答引起的。在过去的几年中，许多与乳糜泻相关的 HLA-DQ 分子限制性的麸质 T 细胞表位已被鉴定。在这项工作中，我们对这些表位进行了概述，并提出了一个全面的、新的命名法。