Satoh K, Katoh K, Murata H, Nishimura S, Yamaguchi H
Division of Nuclear Medicine, Toranomon Hospital, Juntendou University of Medicine.
Kaku Igaku. 1990 Aug;27(8):821-31.
Recently 123I-MIBG scintigraphy has been developed for evaluating the function of cardiac sympathetic nerve. To assess its ischemic damage, dual SPECT with 123I-MIBG and 201Tl-Cl were performed in 24 patients with ischemic heart disease and 8 normal subjects. In order to evaluate extent and severity of ischemic damage, Tl and MIBG abnormal scores were calculated by Bull's eye map. In patients with Non-Q wave myocardial infarction (NQMI), MIBG abnormal scores were significantly higher than Tl scores (p less than 0.01). In the regions where regional wall motion showed hypokinesis, MIBG abnormalities were detected in all cases whereas Tl abnormalities existed only in 42%. MIBG abnormality score in NQMI group with negative T wave and wall motion asynergy was significantly higher than that of NQMI group without T wave abnormality and asynergy (p less than 0.01). Ischemic damage of cardiac sympathetic nerve seemed to contribute to negative T wave and stunned myocardium. 123I-MIBG scintigraphy was thought to be a sensitive and useful method for clinical evaluation of ischemic heart disease.
最近，123I-间碘苄胍闪烁扫描术已被用于评估心脏交感神经的功能。为了评估其缺血损伤情况，对24例缺血性心脏病患者和8名正常受试者进行了123I-间碘苄胍和201Tl-氯化铊双SPECT检查。为了评估缺血损伤的范围和严重程度，通过靶心图计算铊和间碘苄胍的异常评分。在非Q波心肌梗死（NQMI）患者中，间碘苄胍异常评分显著高于铊评分（p<0.01）。在室壁运动显示运动减弱的区域，所有病例均检测到间碘苄胍异常，而铊异常仅存在于42%的病例中。T波阴性且室壁运动不协调的NQMI组间碘苄胍异常评分显著高于无T波异常及不协调的NQMI组（p<0.01）。心脏交感神经的缺血损伤似乎与T波阴性及心肌顿抑有关。123I-间碘苄胍闪烁扫描术被认为是临床评估缺血性心脏病的一种敏感且有用的方法。
