Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
J Breast Cancer. 2011 Dec;14(4):308-13. doi: 10.4048/jbc.2011.14.4.308. Epub 2011 Dec 27.
Mucinous carcinoma (MC) of the breast is a rare histologic type of mammary neoplasm. The objective of this study was to evaluate the long-term disease-free survival (DFS) and overall survival (OS) of MC.
We conducted a retrospective analysis of all MC cases reported to a database between 1994 and 2010. Clinicopathological characteristics and survival of 268 MC cases were reviewed and compared with 2,455 invasive ductal carcinoma-not otherwise specified (IDC-NOS) cases.
The MC cases were of a younger age, involved less lymph nodes, lower stage, more expression of hormonal receptors, and less HER2 overexpression compared to the IDC-NOS cases. The 5-year DFS rate for MC was 95.2% compared to 92.0% for IDC-NOS. The 5-year OS rate for MC was 98.9% compared to 94.9% for IDC-NOS. Multivariate analysis using Cox regression revealed that the mucinous type was a significant prognostic factor for DFS with lower nodal status (N stage) and hormonal therapy. For OS, only N stage was the most significant prognostic factor followed by adjuvant chemotherapy and adjuvant hormonal therapy.
MC was shown to be associated with a better DFS than IDC-NOS, but it had a similar OS. Nodal status and adjuvant therapy appear to be more significant predictors of prognosis than histologic subtype.
乳腺黏液癌（MC）是一种罕见的乳腺肿瘤组织学类型。本研究旨在评估 MC 的长期无病生存（DFS）和总生存（OS）。
我们对 1994 年至 2010 年期间报告给数据库的所有 MC 病例进行了回顾性分析。回顾并比较了 268 例 MC 病例和 2455 例非特殊型浸润性导管癌（IDC-NOS）病例的临床病理特征和生存情况。
与 IDC-NOS 病例相比，MC 病例的年龄更小，淋巴结受累较少，分期较低，激素受体表达更多，HER2 过表达较少。MC 的 5 年 DFS 率为 95.2%，IDC-NOS 为 92.0%。MC 的 5 年 OS 率为 98.9%，IDC-NOS 为 94.9%。使用 Cox 回归的多变量分析显示，黏液型是 DFS 的显著预后因素，与较低的淋巴结状态（N 期）和激素治疗有关。对于 OS，只有 N 期是最重要的预后因素，其次是辅助化疗和辅助激素治疗。
与 IDC-NOS 相比，MC 显示出更好的 DFS，但 OS 相似。淋巴结状态和辅助治疗似乎比组织学类型更能预测预后。
