Kim Hyoung Jong, Kim Byung Hoon, Park Chol Hee, Kim Chun Il
Department of Urology, Keimyung University School of Medicine, Daegu, Korea.
Korean J Urol. 2012 Jan;53(1):9-13. doi: 10.4111/kju.2012.53.1.9. Epub 2012 Jan 25.
A great variety of studies on preoperative serum testosterone as a predictor of progression of prostate cancer have been reported recently. The purpose of this study was to investigate the relationship of preoperative serum testosterone levels in patients who underwent radical prostatectomy with prognostic factors.
Clinical data were collected from 60 patients who underwent radical prostatectomy. The 60 cases were divided into 2 groups according to their preoperative serum testosterone levels: group 1 (n=21), <3 ng/ml; group 2 (n=39), ≥3 ng/ml. The groups were compared according to prog-ression factors. Multivariate logistic regression analysis was performed to determine the correlation between biochemical recurrence and each variable.
The incidence of extraprostatic invasions was significantly higher in group 1 with 13 cases in group 1 (61.9%) and 11 cases in group 2 (28.2%) (p=0.011). The incidence of biochemical recurrence was also significantly higher in group 1 with 5 cases in group 1 (23.8%) and 2 cases in group 2 (5.1%) (p=0.032). A low serum testosterone level (≤3 ng/ml) was associated with an increased risk of biochemical recurrence (odds ratio [OR], 13.64; 95% confidence interval [CI], 1.66 to 2.43; p=0.015) and an increased risk of extraprostatic invasions (OR, 4.96; 95% CI, 1.41 to 17.38; p=0.012).
The incidence rates of extraprostatic invasions and biochemical recurrence were significantly higher in the group with preoperative average serum testosterone of less than 3 ng/ml. Therefore, these results suggest that preoperative average serum testosterone will be useful in predicting postoperative prostate cancer progression.
近期已有大量关于术前血清睾酮作为前列腺癌进展预测指标的研究报道。本研究旨在探讨接受根治性前列腺切除术患者的术前血清睾酮水平与预后因素之间的关系。
收集60例行根治性前列腺切除术患者的临床资料。根据术前血清睾酮水平将60例患者分为2组：第1组（n = 21），<3 ng/ml；第2组（n = 39），≥3 ng/ml。根据进展因素对两组进行比较。进行多因素逻辑回归分析以确定生化复发与各变量之间的相关性。
第1组前列腺外侵犯的发生率显著更高，第1组有13例（61.9%），第2组有11例（28.2%）（p = 0.011）。第1组生化复发的发生率也显著更高，第1组有5例（23.8%），第2组有2例（5.1%）（p = 0.032）。低血清睾酮水平（≤3 ng/ml）与生化复发风险增加（比值比[OR]，13.64；95%置信区间[CI]，1.66至2.43；p = 0.015）及前列腺外侵犯风险增加（OR，4.96；95% CI，1.41至17.38；p = 0.012）相关。
术前平均血清睾酮低于3 ng/ml组的前列腺外侵犯和生化复发发生率显著更高。因此，这些结果表明术前平均血清睾酮对预测前列腺癌术后进展有帮助。
